Dodges your AAs so you can't bring her life under the R execution
Twitch
If you need to excape his poison will spot you anyway
Brand
Same thing as twitch
Renata Glasc
Even if you kill someone that she revives, you won't get your R back. Such a shame
Morgana
Black shield.
Nautilus
Many stuns, and also can counter grab/escape you.
Lulu
She increases max life, so you have to time your R with hers to execute. Also slows and kinda stuns
Rell
She's just tanky, focus the ADC (just stun her if she goes in, she's not unstoppable when engages with W)
Lux
Even if you are difficult to hit with the pyke's movement, pay attention to her R.
Senna
High range but low mobility, engage well and she dies. If you don't, she will shot you to death.
Jhin
Dodge his W and his R and you are good, missplay something and something can go really wrong.
Yuumi
She can mess up your R with just pressing the E key while she's watching netflix.
Caitlyn
Same thing as senna, but her R is auto aimed so becoming invisible wont work.
Leona
Tanky as Rell, but just focus ADC.
Ashe
Dodge R and keep a dash or W to escape her slows.
Zilean
his R counters yours. Gives speed to allies so your R will likely miss.
Zyra
Stuns and extreme poking. but overall you should be able to win if you focus adc and dodge her stuns.
Alistar
he pushes and knocks up enemies + he's tanky. The same think as Rell and Leona :) .
Braum
when you grab he might get in front of his ADC so you grab him. Nice protection but now he's dead...
Janna
Her unpredictable tornados and the R that pushes away can be a lethal weapon against pyke.
Aphelios
You grab he attack, pretty simple combo.
Caitlyn
You grab and stun, she can choose a bunch of attacks that will work (ex: traps, Q, AAs, E, R...)
Tristana
You grab she jumps in with you, stun + AoE bomb.
Ezreal
If you grab in the wrong moment you can let ezreal miss a Q or W reducing the damage output... pay attention!
Twitch
Pierce + attack speed with long range, even if he doesn't follow you in your engage he can still attack... if he wants obviously.
Miss Fortune
AoE slow + AoE ult with your kit is awesome. They are even from the same city!
Lucian
Can follow up very easily but your grab can mess up his ult.
Varus
With the new AP varus build this duo became one of my favorites. Pyke grabs, varus ults, you stun, varus does his Q and if it wont kill, you can execute. Perfect in my opinion
Jinx
Grabs + Traps always good
Samira
Really good but samira needs kills to gain power.
Draven
Really high early damage. With this duo is easy to get first blood.
Vayne
Is strange because you can mess up the stuns each other so i wouldn't recommend this.
Xayah
Overall good, no actual conflict with skills.
Synergies
IdealStrongOkLowNone
Aphelios
You grab he attack, pretty simple combo.
Caitlyn
You grab and stun, she can choose a bunch of attacks that will work (ex: traps, Q, AAs, E, R...)
Tristana
You grab she jumps in with you, stun + AoE bomb.
Ezreal
If you grab in the wrong moment you can let ezreal miss a Q or W reducing the damage output... pay attention!
Twitch
Pierce + attack speed with long range, even if he doesn't follow you in your engage he can still attack... if he wants obviously.
Miss Fortune
AoE slow + AoE ult with your kit is awesome. They are even from the same city!
Lucian
Can follow up very easily but your grab can mess up his ult.
Varus
With the new AP varus build this duo became one of my favorites. Pyke grabs, varus ults, you stun, varus does his Q and if it wont kill, you can execute. Perfect in my opinion
Jinx
Grabs + Traps always good
Samira
Really good but samira needs kills to gain power.
Draven
Really high early damage. With this duo is easy to get first blood.
Vayne
Is strange because you can mess up the stuns each other so i wouldn't recommend this.
Pyke is an assassin that is for some reason in the support role. But he can be played everywhere, for example MID! his kit allows the player to do really cool trades with the enemies. it works top too.
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