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9x Greater Seal of Vitality - i pick these runes because they help alot with survivability early game and providing you with more health so you can spam Q more
9x Greater Glyph of Scaling Cooldown Reduction - i pick these runes because they help alot with cooldowns , Dr.Mundo have small cooldowns but with these runes you can spam all your skills including your ultimate more often
1x Greater Quintessence of Magic Resist - i pick these quintessences because they help you mitigate damage early game
2x Greater Quintessence of Armor - same as above these runes help alot early game against annoying harrasers
You can run different Quintessences if you feel there are better ones to get .
-Q- My favourite Dr.Mundo ability , its his bread and butter. It deals a very good amount of dmg combined with a 40% slow for 2 seconds . With my setup you will have a lot of CDR and you can spam this ability a lot so no enemy will be able to run away from you .
-W- This ability can help you farm lanes faster and in teamfight it provides you with a much needed additional damage so you can finish off your opponents faster . I almost forgot it gives you a much needed crowd control reduction .
-E- Same as the Burning Agony this ability will give you additional damage although you don't have any armor penetration its still a good ability to use .
-ULTIMATE- This ultimate will make you IMPOSSIBLE to kill duo to a HUGE ammount of health regen for 12 seconds , it also gives you 35% movement speed . With my runes/masteries/items you can have your ultimate every 40 seconds .
- 10% cooldown reduction will help you alot early game and 15% regeneration effects will help your ultimate heal through a lot more damage
- some magic resistance and always important tenacity
- more hp = more survivability
- armor,hp regen,cooldown reduction, atk/ms debuff whats not to like?
- this bad boy will make you unstoppable duo to its 40 hp per 5 + unique passive combined with your passive and ult
- good ammount of armor and damage from your 3800+ hp ( you can change this item with other items if you think there is a better choice )