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Introduction
Marks
There is a 2 options here, either use attack damage, to get some damage on both champs and minions, or go with armor pen for great damage on champs.
Seals
Here there is not really an option, you need these runes to survive and not get roflstomped.
Glyhs
Here i prefer Cooldown reduction, but if you want to survive AP carries choose MR runes instead.
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