Welcome to my Vayne AS ADC build.
My name is Shrektum Resizer, and i use to play Vayne a lot so i decided to make a quick guide to help you guys out!

We're going over the pros and cons, what to build on Vayne, and in which order, skill order, her Match-ups, Runes, Summoner Spells, then a summary and last but not least some quick tips and further help.
Hope you guys enjoy it, let's jump straight into it!

+ One of the best hyper-carries.
+ Extremely fun to play.
+ Easy carrying in SoloQ.
+ Has a stun.
+ Can 1v1 almost every single adc. (except Graves)
+ Very mobile with the tumble.
+ W has unlimited damage and no cooldown.

- Really difficult to master.
- Hard to land the stun.
- Easily countered.
- Q has long cooldown if not used.
- Short range auto attacks.

<--- This is your most common item on Vayne, you should build this item as your first item every game when playing Vayne. This is a mix of Damage + Attack Speed and Life steal which is what you need when playing Vayne, also don't forget the awesome Item Activation!ALWAYS get this 1st

Really important item on Vayne, Gives a bunch of Attack Speed and Critical Strike, and helps with farming because of the Passive. USUALLY get this 2nd

Obviously these boots only, but you can swap Homeguard with Furor if you wish, it's just what you personally prefer, though i do prefer Homeguard. USUALLYget this 3rd, but if you aren't that rich could also just buy Boots and upgrade is whenever u want!

Also a really important item when you are jumping into late game because this helps you make your W passive come alive, especially on AS Vayne which refers to this build. (go to AD Vayne Build for other item/skillorder). ALWAYS get this item 4th, because if you want to get it earlier, you should swap it with Statikk Shiv though both are a must have on AS Vayne.

Usually your last Damage item, also the best. Since you're AS Vayne you should get it as your last (damage) item (Go to AD Vayne for a different build). This item gives you the ability to deal tons of damage with ordinary AA's + the crit passive and the crit strike really helps out. This should be a must have but occasionally is switched with Last Whisper. ALWAYS get this item as your last damage item!

There you are, your final item and also your defensive item, now this can be switched with Warmog's Armor or Randuin's Omen (which i won't explain about since it's kinda obvious) You should always get a defensive item and therefore Guardian Angel is the best, giving you the ability to fight twice in a teamfight is great, especially with Vayne because she is such a Hyper Carry. ALWAYS get your defensive item last, except when you get being focused hard and just being killed, then you should swap the order with Infinity Edge.

For our skill-sequence we should level Silver Bolts(every 3rd auto attacks it deals a massive amount of true damage every single time is possible (except if you can level your Final Hour which is on the levels : 6, 11, 16).
You have to max Silver Bolts first because it deals a ridiculous high amount of true damage which means that even if the enemy would buy armor the damage will still be the same amount, but also the more HP the enemies buy, the more damage your Silver Bolts deal, which makes your extremely strong against champion who buy HP in late-game or enemy supports who are building HP like idiots. This is the main reason you max Silver Bolts first.

As 2nd skill you go for your Q Tumble which causes you to make a small jump forward, and your next basic attack to deal extra Attack Damage. ( when you are playing AD vayne you should max Q first. Go for the AD Vayne build in the top-left corner for the AD guide. You should combine your 3rd Silver Bolts with your Tumble to deal tons of damage