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Skill match up. You can take Mercury's Treads and cleanse (so you can use it while charmed or ignited).
You outscale her, so try to stay safety, and call you'r team while she try to roam. Ask you jungler to help you, while she don't get lvl 6.
Akali
Skill match up. Try to dodge her "e" so she can't all in you. Ori is much better in team fights, so try to stay safety at her lvl6
Anivia
Very easy match up. Punish her if she miss "q". Let her push, and stay between her minions and her tower, so she can't farm. Ask you jungler to set vision, so you can't be punished. After lvl 6 be careful, and don't stay beside the wall's, so she can't block you with "w".
Annie
You just deal much more dmg, watch her passive, and don't get gank
Aurelion Sol
Be carefull at lvl 1 and 2, he can do a lot of dmg, but after lvl 3 he can't do ahything to you. If you afraid, take cleanse, otherway dodge his stun and all in him after lvl 6
Azir
Skill match up. He is strong enough at lane, so ask you'r jungler to help. If Azir is rly good, you can't do anything to him. Take Dematerializer and try to win another lane
Brand
Have high dmg potential. but hard to realise. Dodge stan. and you will be fine. Care with 2v2 trades when he take ult.
Cassiopeia
In theory Orianna is a good pick into Cass, but this matchup can fall apart quickly if you fall behind. Her main weakness is that she has to come at you in a straight line to deal her damage which will allow you to land your combo for free. You can trade relatively evenly early and late game. If in a fight she ever misses a Q, you should win the trade.
Corki
This matchup is decently even early game so feel free to trade and pressure him within reason. He powerspikes much harder than Orianna mid game with trinity force, so try to match his roams and power as you hold out until late game. He does do lots of damage late, but he doesn't have the same impact as you do with your ultimate and shields for your team.
Diana
Early levels you can sort of pressure Diana, but a good one will be able to mitigate most of what you do with her shield. If you get enough of a lead pre-6, she shouldn't be a problem. But if she gets ahead at any point, this champion has the serious ability to 1 shot you with just landing a single Q skillshot. With that said, she is overall weak in a team fight setting and just a Banshee Veil should keep you safe. Take exhaust to be safety early.
Zed
Be careful with him and don't stay low hp at lane. Zed has kill pressure on you at every point of the game after level 3. Always respect his shadows and do you best to not let him get a combo that procs his electrocute. Poke him out hard when his W is on cooldown. A stopwatch can be life or death in this matchup, but it won't be up until long after he has Ult. HP and Armor are your best friends in this matchup, but dont build too defensively. Late game you still need to be a damage threat and your team will be able to chain cc and shields to peel whoever he is trying to dive.
Irelia
Irelia is an absolute menace in the mid lane for immobile scaling carries like Orianna. She can kill you from level 2 onwards and throughout you will have very little kill pressure on her without substantial jungle support. Zhonyas is a great early buy into this matchup so that you can avoid her all in if her Ult lands on you. Dont underestimate her ability to jump on you and burst you with just a Q and E once she has Tiamat. Do your best to avoid solo deaths and match her roams in order to minimize her impact. The usual on good thing about this is that their team is likely to lack the magic damage of a control mage in the mid lane. Cleanse can work decently for her stun, but she will likely still kill you. I would recommend either Exhaust or Barrier depending on whether or not you expect her to take Teleport or Ignite.
Fizz
Fizz is a real problem, Build banshee veil as soon as possible (after lost chapter), try to play around his Q and E cooldowns, and be realy careful after he take lvl6. Take exhaust, so you can survive early game
Katarina
Trade her carefully, take exhaust, and never walk near a dagger on the ground.
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