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Vladimir - Sustain in lane
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These runes are aimed at giving you major sustain in lane.
Greater Mark of Magic Penetration gives you great magic pen, which is great against mage-tanks like Galio or against tanks who build magic resist
Greater seal of Vigor gives you great sustain in lane
Greater Glyph of Cooldown Reduction gives you awesome CDR that allows you to keep spamming your skills.
Pro tip: If you get a Will of the Ancients and buy a new Hextech Revolver after finishing the will, you can get up to alot of spell vamp for early game since it does stack.
Mid-game (9-13): This is where you start to be getting some farm under you and start getting some damage, you should never walk in the from lines of battle, let the tank to that, despite your high amounts of hp you don't have any armor or magic resist at all. If you start ganking you should always start with using Hemoplague then Transfusion -> Ignite/ Tides of Blood and if you choose to chase Sanguine Pool to slow the enemy.
Late-game (14-18): This is very much the same as before, don't initiate, let the tank, remember to keep an eye on dragon and baron. If you get into a teamfight, focus the ad carry or the ap caster, if you find yourself focused just pool and/or use Zhonya's Hourglass this is more than enough time for the enemy to either switch their focus or die. And remember to always start out with your Ult!
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