Here are 3 variants.

1. Your standard runes:
2. Against a botlane without ap

3. Zero magic resist if you have balls

You can choose between this 3 pages. The first one is the most confident page and the last one is the most risky page.
It's your decision.

This should be your standard masteries for Lucian. You can also take Warlord's bloodlust () in the ferocity-tree but i think that Fervor of Battle is the best because you can easy get the stacks on it with your passive.

LIGHTSLINGER (Passive):

Try to use it after every single spell and dont use 2 spells in a row.
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PIERCING LIGHT (Q):

One of your most important spells! You can easy farm with it and have a good poke
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ARDENT BLAZE (W):

Just skill it for the passive movement speed and your passive.
If you hit enemies i a bush you get vision over them.
Poke = waste of mana
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RELENTLESS PURSUIT (E):

In a fight try to use it as ur first spell. Because you can reduce the cd of this spell with your passive. (example combo: E-AA-Q-AA-W-AA-E)
Keep this spell for skillshots from enemies (like Blitzcrank's Q)
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THE CULLING (R):

You can use Flash or your E during your ult.
Can be canceled by upknocks, hooks, charms (etc.)
You can use it if the enemy stays with low life under his turret because it has the biggest range

You can use your Q to last hit 2 or more creeps and poke the enemy adc/support. Your mana costs are low but you need to look at your mana.

Under turret:
Melee minion: wait 2 tower shots then you can take him
Caster minion: wait 1 tower shot and use your E to take him./ Make 1aa, 1 tower shot, 1aa./ if you got bf, you can wait 1 tower shot and make 1aa

Stay in the backline and keep you should keep your E ready. You can use it to go agressive but don't facecheck stay behind your team. You can use it to disengage too.
Just focus the enemy backline if they stand next to you, but dont focus just them and ignore their frontline. If needed focus the one next to you.
Use your E too doge their cc like:
Wait until the enemy apc is out of his combo and start fighting.