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Recommended Items
Runes: ARAM Runes
+10% Attack Speed
+9 Adaptive (5.4 AD or 9 AP)
+15-140 HP (lvls 1-18)
Spells:
Flash
Mark/Dash
Items
Threats & Synergies
Evelynn
A fed Evelynn is a major problem. Evelynn can take down 6K HP Cho'gaths in under 2 seconds. You won't have as much bulk as a Tank Cho'gath. If you gets to you with her combo, you are screwed. Plus, she has invisibility when not attacking after level 6. Just be wary and watch her movement. You might be able to stop her with a well-timed cleaver.
Champion Build Guide
Turrets in your way? The bag is enough. An ADC has their eye on you, your heavy bag and cleaver are just what you need to fix their sight! With this kind of build, Dr. Mundo can really pick up the pace and start helping as many of his patients as mundo-ly possible!
So why am I saying this? Because it explains why my item kits and runes are fitted solely for ARAM (and maybe URF). I discovered this build when I got so tired of playing Tank Mundo and I realized his E counted as an empowered basic. From there, I made a short list of items typically seen on semi-tanky, one-hit type bruisers (so basically Nasus). It's not exactly the kind of "mathematically correct" stuff that's been going around the last few months, but it is pretty dang close after this game proved it:

The time says it was a 31 minute ARAM game, I averaged over a kill per minute and the higher-than-normal CS for a Mundo came from me hitting one minion and clearing the entire wave when I had my core items. (If you're curious about champion damage, the opponent team had a Karthus, one of the super-nukers in ARAM, and I outdamaged him by 15K!)
Your first target item is actually Titanic Hydra rather than your Mythic. This grants a massive damage boost when using E and the blast cone is a hazard to opponent champions so they tend to avoid it. Otherwise, throw some cleavers and carry on. If they do end up avoiding it, this means you can start farming minions, blasting the dead ones toward the opposing team. The blast cone can also have some odd effects like odd E blast directions and ultimately heavier collateral hits.
A video from Twitter: https://twitter.com/i/status/1440191458892402703
If you don't have enough, buy a Sheen instead and whatever else you can. Buy boots even if you don't have enough for a Long Sword or a Ruby Crystal.
Your next item is going to be either Divine Sunderer or Trinity Force. Most often than not, go Divine Sunderer. Your healing off of your E will be massive and the extra max-HP damage to go with the growing power of your E is just amazing. It also grants the Mythic passive of mixed penetration. Mundo's Q and W deal magic damage which is affected by MR so more penetration grants more damage all-around. The rest of Mundo's attacks come from swinging his bag and chopping with his cleaver which means having armor penetration once again just means more damage (and who doesn't want more?)
Your third core item must be Warmog's. At this point, you probably already have your Overgrowth and Grasp well enough stacked that when you buy this, your healing will be immense. Just having Titanic Hydra alone before buying Warmog's is enough for the new passive, but adding the Sunderer and other HP growth is just perfect. Warmogs gives a huge regeneration boost even without its passive and having some AH is always nice.
Your last three items are up to you. I have just some suggested item paths, but it's entirely your choice! I typically end up selling my boots in favor of being extra-tanky, but you don't have to (especially if your opponents are very cc heavy. Then buy a QSS or keep your boots!).
This might be viable in Ranked. I don't know. I don't play it. But if it does work for you, then you've got yourself a winner.
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