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Pros + Has an amazing poke + Does a lot of poison damage + Has very fast casting + Can both slow and stun + Has very high damage

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Cons - Squishy - Hard to master - Depends highly on mana - Huge target - Skill shots

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Summoner's Wrath improves ignite and exhaust Brute Force increases attack damage. Butcher Deals bonus attack damage to basic attacks on monsters/minions. This is good for when you are farming, as well as granting you more last minion kills and more gold. Sorcery increases cooldown reduction. Good to use so that Petrifying Gaze does not take as long to cool down. Demolitionist increases the damage done to enemy towers. This can be useful throughout the entire game, rather than other masteries that are meant to aid you in early or late game. Arcane Knowledge will increase magic penetration, a key aspect to being a successful Cassiopeia Blast increases ability power. Because you are building Cassiopeia through AP, this is important, because it will also allow you to add masteries to Archmage Archmage increases ability power, to add on to your AP build. Executioner helps to finish off weak enemies

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Summoner's Insight improves flash and teleport, two of the possible suggestions for summoner's spells to take with you. Good Hands reduces the amount of time dead. Only put one point into this because it is not as important as other masteries. Also, remember that it is better to stay alive longer than come back to life quicker. Expanded Mind increases mana. Overall, the more mana the better because Cassiopeia needs a lot of mana, especially if she is farming or midding. This is good to pair up with the Runic Affinity so that if you get the blue buff, you will have no trouble. Meditation increases mana regeneration. Cassiopeia seems to use up a large amount of mana with many of her spells, even with her Deadly Cadence. This is more important for the beginning of the game, since by the end it will seem like you have an endless supply of mana. Runic Affinity increases the duration of shrine, relic, quest, and neutral monster buffs. This is important to take with you so that when your jungler gives you blue, you will have much quicker mana regeneration up until the point that you build your Athene's Unholy Grail.

Ignite is one of the most helpful spells you can have. Since Cassiopeia can deal so much damage because of Deadly Cadence it is very likely that there will be a point when the enemy will want to recall. Having ignite with you can be the difference between killing them and letting them come right back with full health and mana.


Although exhaust is normally seen as offensive to chase enemies down and slow them, Cassiopeia already can slow with Miasma and with every ability after she buids Rylai's Crystal Scepter. That being said, it is good to use when being ganked to slow down and defensively escape.


Flash is also very important since Cassiopeia is very squishy. Being able to either escape, chase an escaping enemy, or pass through walls/trees is very helpful in that key moment.


The reason why I like teleport for Cassiopeia is because many people believe that she can only mid. Because of that, you can use it to surprise enemies at other turrets, and ultimately play the field as much as possible



Ghost is one of those spells that I have not used very often, but can be very effective if executed correctly.


For Cassiopeia, mana is probablly the one thing that you will find scarce. Because of that, I already have you building Athene's Unholy Grail early off in the game. However, if you want that extra boost, you can bring clarity with you so that you don't have to recall so many times.



I have never found much usage for cleanse. It helps in certain situations, but I figure that if you can only bring two summoner spells, I want them to be two that will help Cassiopeia the most; and this is not one of them.


Smite is a spell that I only bring when I am jungling. If you take on the role of a jungler with Cassiopeia and are successful, then I applaud you. Overall, she does not do as much damage as is needed to be a jungler. It is possible, but not recommended.


Once again, this is one of those spells that is completely situational. However, it could be completely useless if used the wrong way, which is why I prefer to stay away from it, and use those spells that I know can help me in the end.


This spell can be good in some situations, but stay away from it. There are other spells that can help you out so much more in battle, and if you already are using Good Hands then the amount of time you spend dead is already decreased.

There's a specific reason why I chose the ability and skill sequence that I have for this build. Even though I have seen this and many others in different guides, this is the one sequence that I have played in games and has always worked for me. The reason why I like to max out Noxious Blast first is because it is your poke. It is your first ability since it will poison and do damage, and has a long range. It is your first ability maxed to level 5 because it will do major damage, and can be later paired with Twin Fang. That is going to be your second move maxed out. When an enemy is poisoned, it has rarely any cooldown, and uses less and less mana due to Deadly Cadence. That being said, you can kill an enemy champion in a matter of seconds. Your third basic ability is Miasma. The reason why that is the last basic skill that you are maxing out is because it costs much more mana than the other two, and is not as reliable when it comes to a team battle. It does slow, but that is not as important if you build the right items. However, when you do finally reach levels 4 and 5 with it, it can be a lifesaver, and help you to escape by slowing any champions giving chase. Finally, we have your ultimate ability. Petrifying Gaze is a fantastic move, because it will do massive damage to enemies in addition to either stunning them or slowing them, based on how skilled you are. Timing with this move is key because you want to make sure that not only your enemy is facing you when you cast it, but that if a team of enemies is chasing you, that most of them if not all of them are facing you when you cast it. It does require training to master, but it super effective once it is.

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These boots will give you 20% increased magic penetration. That is important because you are already building magic penetration using your masteries and runes, in addition to any other items that may increase it.


This item is optional. I like to have a higher attack speed, especially for farming. The reason why I like this item better than other attack speed items is because it grants you mana regeneration and ability power as well.

Gives you SO much ability power. If it weren't for this item, I don't know what I would do whenever I play Cassiopeia. This paired with other items giving you AP and runes/masteries adding to that will give you so much damage whenever you cast a spell.


This will increase health and mana, which are both very important to using Cassiopeia, as well as granting you 50 magic resistance. The mana is especially important since you can easily run out of mana when you are spamming Noxious Blast.


Again, this is an optional item. In certain situations, it has worked out very well for me, especially when being ganked by the enemy team. If you do choose to use this, save it for one of your last items because there are other more important builds to have first.


I mainly choose this item because Cassiopeia relies on mana. Building this up in the the middle of the game secures that you will have a huge amount of mana regeneration, in addition to shorter cooldowns. Don't rush into it because you will have enough mana regeneration in the beginning with Chalice of Harmony until you decide to upgrade it.


The reason why I like this item is because it gives you a lot of extra health, which is important (especially when mixing it with Warmog's Armor because it can save Cassiopeia from numerous deaths. In addition to that, it builds a massive amount of ability power, which is what guides her spells. Also, it will allow you to slow enemies with any of your abilities, so that you do not have to rely on Miasma. If you can hit Noxious Blast perfectly and slow your enemy, then your combinations can be very effective.


This is another optional item. It does not give you any ability power, but the extra health can help you out. However, if up against an AD carry, this may not help you out as well as other items would.


I like the ability power that this item gives you, as well as the huge increase in magic penetration. Overall, it does help out a lot.

For each of my runes, I tried to pick out the 4 things that I find most important to Zyra that would help her to thrive in battle.


•Magic Penetration
•Ability Power
•Mana regeneration




The reason why I choose the Greater Mark of Magic Penetration is because it is being paired with other items and boots that increase magic penetration by percentages. If you take those items with you while having a magic penetration level of 1, then odds are you won't get it much higher than 3. By adding runes that will increase you magic penetration from the start, you can successfully play in the beginning of the game until the end of the game.



The reasoning behind picking the Greater Seal of Replenishment is because you want to build up fast mana regeneration. Since you are not making your Athene's Unholy Grail until mid game, you want to make sure that you have increased mana regeneration for Cassiopeia because as time goes on, and you level, you are going to realize how much Noxious Blast can take a toll on your mana levels.



The reason why I chose the Greater Glyph of Magic Penetration is because ability power can either make or break you as soon as the game begins. Overall, all of the spells and abilities that Cassiopeia uses are significantly effected by ability power, and many of the items chosen for her build will increase it by a percentage, in which case more is better. The reason why I chose to gradually gain more as you level is because in the end, you have significantly more ability power than you would have if you had taken other glyphs granting you all the ability power right away.



I chose the Greater Quintessence of Ability Power because usually the first kill happens before minions even spawn, so it is important to make sure that you have the ability power to either defend yourself against an oncoming enemy or to be the one drawing first blood. The reason why I choose this time to take all of the ability power at once rather than get more gradually as Cassiopeia levels up is because there is not as huge a difference between force and potency when it comes to the quintessences.

Although I do not prefer playing the top or bottom with Cassiopeia she still does just as well. In some instances, she can even do better based on who she is up against. Right from the begining, Noxious Blast can be used to hit both enemy champions if you have a sight ward in the second brush, giving you a large lead, and possibly two kills if your ally is with you. In addition, as time goes on, Cassiopeia is still a very good pusher in many instances, and is able to quickly take down turrets if played the right way.

Do I suggest jungling as Cassiopeia? NO WAY! Even though it is possible, it is just a simple fact: Cassiopeia. Is. Not. Meant. To. Jungle. Leave the jungling to your Shaco or Warwick because you can aid your team so much more in the middle or other lanes. The one jungling aspect which I do suggest for Cassiopeia is getting the blue, because you need the mana. In the beginning of the game you may want to get someone to leash it, but later on it most likely won't even be necessary to get it because of your Athene's Unholy Grail giving you high mana regeneration.

Deadly cadence is a perfect spell for Cassiopeia since she relies so heavily on mana. It gives you the ability to cast multiple spells or abilities in a row for less mana than it would normally cost.

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Noxious blast is your poke move. You can use it on enemies in order to poison them and do damage. The reason why yo want to maz out this move first is because you can pair it with Rylai's Crystal Scepter so that it also slows enemies. In addition to that, you need to make sure that you practice using it before jumping right into a PvP. This move is a skill shot move, because as soon as you click your "q" it goes into effect, unlike other abilities where a target will show up first. It can be hard to land, but is super effective when it is mastered.

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This is supposed to be your last move maxed out. It does slow, but it only poisons, and does not do any further damage besides the damage from that poison. It can be seen by enemies, but can still be effective if done correctly. It does aid before you build up Rylai's Crystal Scepter because of its slow, but is also better to be mastered before you go into a PvP.

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The reason why twin fang is one of my favorite moves is because if it hits a poisoned target, it has literally no cooldown. It does massive damage, but also requires a lot of mana. However, if you time it right and cast it correctly with Deadly Cadence then you can find yourself killing your opponent in a matter of seconds.

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This move can either stun or slow your enemy, which is why you want to make sure that you master it also before you enter a PvP. It can be used offensively in order to stun an opponent, do damage to them, then follow up with other abilities, or it can be your lifesaver, and stun them as you make you escape with 10 health. However, even if you miss your target and they are turning the other way, it is nice that it will also slow your enemies.

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Throughout a series of tests and games, I found that there are 3 different combinations that I have found for Cassiopeia. These consist of early game, mid game, and late game combinations. Each combination is similar but unique from each other at the same time because of its end effects.

Early Game Combination - By this point, I would hope that you have a strongish Noxious Blast. Your other abilities are all lower level, and will act as support for after you attack your enemy with your "q". It can also be paired with Ignite so that you can guarantee the kill.

Mid Game Combination - By this point, you will have a strong Twin Fang as well as Noxious Blast. You still do not have your ultimate ability, but you can still do major damage by first slowing your enemy with Miasma.

Late Game Combination - Finally by this point, you should have all of your abilities, and can use the final combination that follows. You want to use your Miasma first to slow, but put it behind your enemy, then quicky use your ultimate to stun them or slow them. This way, even if your stun misses, they will be slowed massively by both Miasma and Petrifying Gaze. Then, work your magic with the rest of your abilities.

You always have to remember that you are only as strong as your weakest link. This isn't an individual game, it's a team game, and there's no I in team. That being the case, make sure that you have a well balanced team before you even choose Cassiopeia as your champion.


• Twitch
• Teemo
• Singed


All 3 of these characters use poison, which is key to using Twin Fang. Pairing up in a lane with one of these champions would be fantastic.


• Brand
• Ahri
• Zyra
• Ryze


Be careful not to have too many ranged mages on your team. You still need to take a tank with you like Sejuani or a fighter such as Jayce.


• Tristana
• Jax
• Lee Sin
• Soraka
• Karthus

Throughout trials I have also found these champions to work well with Cassiopeia in the same lane. Overall, the range that Tristana offers helps when you are going in to attack with Noxious Blast. Pairing that with a slow and/or stun can leave enemies dazed. I have always seen good combinations with Jax because of his move where he jumps into an enemy and attacks, taking a huge toll on the enemy's health as well. Lee Sin can dash up to an enemy if they are trying to escape, which is important because I have seen many times that you can rush into an enemy too quickly and they go and recall because of the damage your poison does. Soraka is a great partner to have because of her healing abilities and the fact that she can attack a huge area of enemies. And finally, Karthus has shown to be a great ally because of his ultimate ability, which also aids in killing off weak enemies.


• Morgana
• Fizz


Watch out if you are midding against either of these champions. Fizz has a strong utimate ability that can slow you and deal massive damage, while Morgana is a very strong farmer and has useful crowd controls.

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Now that you are past champion selection and in the game, you want to make sure that each lane is evenly balanced. If you are on a team with an Annie then perhaps they should go mid, especially if that means you could lane with one of the suggested champions listed before.


Cassiopeia is a good choice for if you want to go in with a gank, since you can put miasma down slightly behind enemies, then help finish them off. Overall, just make sure that if a team mate needs help, that you go with them, because the second there's an ace, you can say goodbye to a few turrets.

Farming is very easy using Cassiopeia due to her Noxious Blast. However, make sure not to overuse it in the beginning of the game, because you don't have your Athene's Unholy Grail yet, and you could just end up without any mana when you need it. Make sure that when you're farming, go right in the middle of minions when you cast because you want to poison all of them, in order to get the last kill on as many as possible.


The other precaution I have when farming is if you are midding. If it feels like you're farming without any trouble and that there are no champions around, they may be planning a gank. To avoid this, I would suggest leaving a Miasma where the minions were so that they are poisoned and you can still get the last kill, then back up far enough that if needed, you could escape.

*Make sure that you don't max out Miasma first. So many people fall victim to that because they think that it is better to slow their enemies. However, in the end you will find that when you do this, you also get ganked much easier, and enemies don't walk through the big purple spot on the ground.


*Make sure to check your team's composition before choosing Cassiopeia because you may just find that she is not the best fit for that specific scenario.


*Make sure to make usage of Deadly Cadence by casting spells right after that first one. However, don't waste them if you don't need them. It's almost like a buy one tie get one 50% off..... but you only need one tie. So why spend another $15 on one that you're not going to use?


*Make sure that Petrifying Gaze is used when as many enemies as possible are facing you. And, it can be used either offensively or defensively.


*Watch out for any ganks! Cassiopeia is squishy, and even though she can slow, you can find yourself dead if you get over confident. TO avoid this, you can place down Miasma to slow your enemies and do poison damage if being chased.


*Make sure that your enemy is poisoned before using Twin Fang because otherwise the cooldown might take awhile.


*Don't rush into certain items, because you need to make sure that you space them out. If you just go to build up one good item at a time, you will find yourself at a disadvantage to enemies with 3-4 semi-good items that will later build into fantastic items.

I hope you guys all enjoyed my guide! If you are looking for the queen of ability power, then make sure to try out Cassiopeia because if you use her right, then you will be unstoppable!


If you guys liked my guide, then make sure to vote it up, as well as send me any scores that you may get by using it so that I can add you to the Hall of Fame/Results page


Also, I am completely open to any constructive criticism that you may have, and open to any suggestions that you may want added into the guide. The following people have helped to make this guide possible:


•ThaKinetic - many good points on things to change and helpful tips
•IceCreamy - I would never know how to make the columns without your guide, and you played a huge role in the design of my guide.
•jhoijhoi - Your guide on how to make a guide is what got me started, and none of this would have been possible without it.



Also, make sure to check out my other guides! Currently I have guides for the following characters:
• Zyra


P.S. I will probablly upgrade this guide a lot, so make sure to check back!