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Cassiopeia Build Guide by Commercialized

AP Carry Cassiopeia: The Serpent's Embrace (In-Depth)

AP Carry Cassiopeia: The Serpent's Embrace (In-Depth)

Updated on December 1, 2013
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League of Legends Build Guide Author Commercialized Build Guide By Commercialized 170 26 1,266,892 Views 63 Comments
170 26 1,266,892 Views 63 Comments League of Legends Build Guide Author Commercialized Cassiopeia Build Guide By Commercialized Updated on December 1, 2013
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LoL Summoner Spell: Ignite


LoL Summoner Spell: Flash


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Middle Lane
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Middle Lane Ranked #74 in
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More Cassiopeia Runes


While her sister Katarina has always been the most celebrated member of the household, the Du Couteau family has a long history of service to Noxus. It has often been said that no soldier has ever been as fortunate as General Du Couteau to have been graced with daughters. His youngest, Cassiopeia - despite lacking her sister's killer instincts - was equally renowned in court for her stately character and elegance. Cunning as she was beautiful, the temptress could never be found far from the arm of any foreign dignitary, her wiles prying secrets from the lips of even the most wary attache. With the Noxian barbarian pacification campaign having ground to a standstill, Cassiopeia had set her sights on a diplomat from a tribe of the Freljord region. Thinking him an easy mark, the scheming seductress set about beguiling him. He refused to confide in her, however, until she swore an oath of secrecy upon his sword - a strange weapon with a serpentine curve to the blade.

Once her tryst was over, Cassiopeia provisioned her father with information regarding the barbarian resistance. As she divulged this intelligence, a wave of revulsion washed over her. She screamed in agony as her silky skin hardened to scales, her lustrous hair thickened to leather, and her manicured fingernails sharpened to claws. Dazed, she fell upon a group of horrified servants, rending them limb from limb in a heartbeat. When it was over the blood-soaked figure was no longer the ravishing jewel of the Noxian court, but a horror trapped somewhere between woman and serpent. Unable to serve in her traditional capacity, Cassiopeia departed for the League, continuing her service to Noxus on the Fields of Justice.

We have had the #1 Cassiopeia guide for the majority of season 3 (Recently pushed down to Number 2). Let's get back to the top everyone!
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Pros / Cons

space Pros
+ Has an amazing poke
+ Does a lot of poison damage
+ Has very fast casting
+ Can both slow and stun
+ Has very high damage
space space

space space Cons
- Squishy
- Hard to master
- Depends highly on mana
- Huge target
- Skill shots
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Before the new masteries came out, I had a long explanation for each individual mastery and why it would help you.

Although you may wonder why I don't do a 21/0/9 in favor of offense, I find utility to work much better with Cassiopeia because when you get your movement speed from hitting a champion with your q ( Noxious Blast), as well as slow down your enemy using your w ( Miasma), you are given much more time to get the kill, and less likely to let your opponent escape.

In addition, the gold bonus comes in handy because early game you will be squishy, so you want to get items to protect yourself as quickly as possible.
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Summoner Spells

Suggested Summoner Spells

Ignite is one of the most helpful spells you can have. You can either use it with the poison that Cassiopeia has to offer in order to secure a kill on a fleeing enemy, or use it just to weaken/scare enemies into pushing too hard at a certain point. However, you may not always want to bring ignite if you are not an aggressive player. Due to Cassiopeia's squishy nature a better option would be to get something like barrier.

Although exhaust is usually only taken by supports, and critics may say that why take exhaust when you can take ignite, the fact of the matter is that a combo with Miasma which will slow enemies, as well as with exhaust, all mixed together with the damage potential of twin fangs when attacking a poisoned enemy, you are actually more likely to get the kill than if you were to ignite, increasing the chance of missing your miasma or other skill shots.

Flash is the one summoner spell that I would always take. I've seen so many over the wall flashes and last second life saves because of it, but there are other options as well. If one is not taking flash, I would suggest either barrier or ghost for a successful escape route.

The reason why I like teleport for Cassiopeia is because many people believe that she can only mid. Because of that, you can use it to surprise enemies at other turrets, and ultimately play the field as much as possible

Other Summoner Spells That Are Acceptable

Ghost is one of those spells that I have not used very often, but can be very effective if executed correctly. However, it does not have the same effect as teleport in which you can easily trick enemies with your jukes, but the getaways are still very similar.

Early game,mana is important for Cassiopeia. Although I do not ever use Clarity, it is a safe bet for a more conservative player who wants to max out miasma first. I would not suggest taking this summoner spell if you are building either Athene's Unholy Grail or Tear of the Goddess because it will become useless later on in the game, and if you have a good jungler, they will give you many of the blue buffs throughout the game anyways.

Summoner Spells To Avoid

I have never found much usage for cleanse. It helps in certain situations, but I figure that if you can only bring two summoner spells, I want them to be two that will help Cassiopeia the most; and this is not one of them. I have seen amazing plays by professionals when spectating them with cleanse, but it still may not necessarily be the BEST choice.

Smite is a spell that I only bring when I am jungling. If you take on the role of a jungler with Cassiopeia and are successful, then I applaud you. Personally, even though I have had sucessful experiences when testing a Cassiopeia jungle, I do not think it is the most viable lane choice, and do not believe that smite should be one of the summoner spells to take.

Personally, I only take clairvoyance when I am supporting with Taric or jungling with Sejuani. The reason why is because although it is very underused, it is also a very strong summoner spell if used correctly, and you need to always have an escape route. For Taric, a simple stun can help you to get away alive, and for Sejuani her artic assault acts just as well as flash would. However, Cassiopeia doesn't have any reliable escape routes; yes her Miasma can slow enemies giving you the possibility of escape, but it is a risky chance to take.

Don't take revive. Early game, how long do you really have to wait to respawn... like 10 seconds? Yes, perhaps using revive later game in a long game could allow you to skip the 60 second wait, go in with your stun at the enemy tteam trying to push your turret, and poison them with AoE damage and possibly get a kill or two, and allow your team a fighting chance, but the truth of the matter is that many games last 20-30 minutes, and you may not even get that chance. Personally I do not think revive should ever be used unless in dominion.
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Skill Sequence

I've heard many people ask why I don't max out Twin Fang or Miasma first. Rather than tell you why I do max out Noxious Blast first, I will justify my reason for not maxing out those first. Twin Fang definitely has high damage potential due to its instant cooldown if used on a poisoned enemy (which shouldn't be too hard with all of the poison that she has to offer). However, as leveled up, it does become mana costly and only uses an extra 55% of ability power for damage. Miasma I really only use for 3 possible reasons. First, being to check brush because it will give you 7 second sight like a ward would of that brush. The second reason is if I am about to go in for the kill, then you would throw it behind the enemy so that when they try to flee, they are slowed and have fallen right into your trap. The third reason is if you are facing a very aggressive enemy who is trying to shut out your farm and moving around, making it harder for your noxious blast to land. In this case you would throw down a miasma right where the champion is in a ball with the minions, and this way you would get farm from the minions when getting the last hit, as well as do some damage to the enemy champion in the case of them trying to jump you for the kill.

space space space space space space space space
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Final Items

These boots will give you 15 increased magic penetration. Since you are already building magic penetration using your masteries and runes, this will allow you to do more damage to enemies that are attempting to counter you with magic resist.

Since you will be building up Cassiopeia as an AP carry, Rabbadon's is one of the items that you want to build earlier on. All of Cassiopeia's abilities include extra magic damage based on a percentage of her ability power, and with the unique passive for deathcap giving you 30% more ability power, you quickly become a power to be reckoned with.

I definately love Banshee's Veil if you are trying to build just a little more tanky. It works well with Liandry's Anguish, but I would not suggest taking it with Rod of Ages just because when you begin to go overboard with the tankiness, you are losing the vital ability power that Cassiopeia needs. Yes, she is squishy, but you need to remember your role; you are not your team's tank, you are an ap carry.

Any item that gives you 120 ability power off the bat is a good one, but what I love about deathfire is the unique active, working similar to that of Blade of the Ruined King. Paired with poison, a possible ignite, and the burn from Liandry's Anguish, the amount of over a period of time damage you are doing is insane, and it definitely helps if trying to take down a tankier opponent.

Noxious Blast becomes pricey after a few levels are put into it, so mana is definitely of concern. I would not take this and Tear of the Goddess, and soemtimes would take neither but it is a good item for Cassiopeia because of how mana dependent she for her poke, and the ability power is a nice bonus.

The main reason why I usually would take Rylai's over Rod of Ages is because of the unique passive which will slow enemies hit by one of your abilities. The reason I love this is because your miasma slows enemies already, and your poke, Noxious Blast, grants you movement speed when it hits an enemy so it allows you the chance to catch an opponent who either flashed or got away quicker than you could get to them.

Between Rylai's and RoA, i would take Rylai's, BUT in certain cases, taking Rod of Ages could be more beneficial. The main reason I have taken this instead in games is if your opposing team is very tanky. This item, with the stacking bonus every minute you have it, gives you more tankiness and mana potential to allow you to harass for longer periods of time in game, but does not have the slow that Rylai's does. However, it is still a vaiable selection for an item and works well with Cassiopeia.

The ability power that this item gives you, as well as the huge increase in magic penetration overall help out a lot, and is perfect when matched up with your masteries and runes that add magic penetration. The reason that I like to take it is that recently I've seen more people investing at least one of their item slots to magic resist, if not more.

This is one of my favorite items in game because I used to love Haunting Guise but people on my teams would tell me that it is useless and that I should chance it for something else... then season 3 came. When they buffed it and introduced the new addition of the guise being an ingredient for the brand new Liandry's Anguish, I was extremely pleased, and the burn works amazingly with Cassiopeia's poison.

I love all three of the items which give you 120 ability power, but I especially love this one for Cassiopeia because she is squishy, and the extra armor and unique active is helpful in ganks. The active works similarly to the Lissandra ult where you are shielded from incoming damage.

The main perks to this item is the magic resist. Personally, I do not usually build this because most of the time if you have an AP support on your team, they will build it.

It works amazing with your Twin Fang combination on a poisoned champion because of the damage potential. In addition, I love the speed bonus in combination with your Noxious Blast which will also grant you extra speed for a short period of time after hitting an enemy.
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For each of my runes, I tried to pick out the 3 things that I find most important to Cassiopeia that would help her to thrive in battle.

•Magic Penetration
•Ability Power
•Mana regeneration


The reason why I choose the Greater Mark of Magic Penetration is because it is being paired with other items and boots that increase magic penetration by percentages. You want to increase magic penetration as much as possible so that you can take down your opponents faster.


The reasoning behind picking the Greater Seal of Mana Regeneration is because you want to stay in lane as long as possible early game without dying or having to revisit the shop. Cassiopeia eats mana like it's her day job when poking with Noxious Blast so if you do not plan on including either Seraph's Embrace or Athene's Unholy Grail into your build (which I usually do not) then you want something providing you with extra mana regeneration.


The reason why I chose the Greater Glyph of Scaling Ability Power is because ability power can either make or break you as soon as the game begins. Overall, all of the spells and abilities that Cassiopeia uses are significantly effected by ability power, and many of the items chosen for her build will increase it by a percentage, in which case more is better. The reason why I chose to gradually gain more as you level is because in the end, you have significantly more ability power than you would have if you had taken other glyphs granting you all the ability power right away.


I chose the Greater Quintessence of Ability Power because the greatest build that I have found for Cassiopeia is just a pure ability power build, and the quintessences will give you the boost you need early game to possibly get first blood, and if not to at least get semi-fed if not completely fed.
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Choosing Your Lane

Playing The Middle Lane
It is obvious that Cassiopeia does her best when she is mid, there is no question about it. She is very good when going 1v1 against another champion due to her high spell damage potential, and quick cooldowns.
Some tests that I have done for other games:
Cassiopeia Jungle - Successful but not recommended
Cassiopeia bot with Teemo - Sucessful but hard to get one of them fed
Cassiopeia solo top - failure
Cassiopeia and an adc bot - Neutral, it was not necessarily the best option, but worked decently.
Cassiopeia duo top with Singed- Successful
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Abilities & Combinations

Deadly Cadence

Deadly cadence is a perfect spell for Cassiopeia since she relies so heavily on mana. It gives you the ability to cast multiple spells or abilities in a row for less mana than it would normally cost.

Noxious Blast

Noxious blast is your poke move. You can use it on enemies in order to poison them and do damage. The reason why yo want to maz out this move first is because you can pair it with Rylai's Crystal Scepter so that it also slows enemies. In addition to that, you need to make sure that you practice using it before jumping right into a PvP. This move is a skill shot move, because as soon as you click your "q" it goes into effect, unlike other abilities where a target will show up first. It can be hard to land, but is super effective when it is mastered.


This is supposed to be your last move maxed out. It does slow, but it only poisons, and does not do any further damage besides the damage from that poison. It can be seen by enemies, but can still be effective if done correctly. It does aid before you build up Rylai's Crystal Scepter because of its slow, but is also better to be mastered before you go into a PvP.

Twin Fang

The reason why twin fang is one of my favorite moves is because if it hits a poisoned target, it has literally no cooldown. It does massive damage, but also requires a lot of mana. However, if you time it right and cast it correctly with Deadly Cadence then you can find yourself killing your opponent in a matter of seconds.

Petrifying Gaze

This move can either stun or slow your enemy, which is why you want to make sure that you master it also before you enter a PvP. It can be used offensively in order to stun an opponent, do damage to them, then follow up with other abilities, or it can be your lifesaver, and stun them as you make you escape with 10 health. However, even if you miss your target and they are turning the other way, it is nice that it will also slow your enemies.


Throughout a series of tests and games, I found that there are 3 different combinations that I have found for Cassiopeia. These consist of early game, mid game, and late game combinations. Each combination is similar but unique from each other at the same time because of its end effects.

Early Game Combination - By this point, I would hope that you have a strongish Noxious Blast. Your other abilities are all lower level, and will act as support for after you attack your enemy with your "q". It can also be paired with Ignite so that you can guarantee the kill.

Mid Game Combination - By this point, you will have a strong Twin Fang as well as Noxious Blast. You still do not have your ultimate ability, but you can still do major damage by first slowing your enemy with Miasma.

Late Game Combination - Finally by this point, you should have all of your abilities, and can use the final combination that follows. You want to use your Miasma first to slow, but put it behind your enemy, then quicky use your ultimate to stun them or slow them. This way, even if your stun misses, they will be slowed massively by both Miasma and Petrifying Gaze. Then, work your magic with the rest of your abilities.
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Team Play

You always have to remember that you are only as strong as your weakest link. This isn't an individual game, it's a team game, and there's no I in team. That being the case, make sure that you have a well balanced team before you even choose Cassiopeia as your champion.


All 3 of these characters use poison, which is key to using Twin Fang. Pairing up in a lane with one of these champions works well because your cooldown of that ability can be instant after each attack if timed correctly, and can do massive damage to champions.


Throughout trials I have found these champions to work well with Cassiopeia in team fights. Sejuani is useful when she ults, because right as soon as she ults, you can throw down a Miasma, hit a large number of enemies with noxious blast, use your ult to hold them there longer by stunning/slowing them, and twin fanging while your teammates do damage as well. The Taric stun and Amumu stun also work very well, allowing you to do massive amounts of damage before they even have a chance to hit you. Yorick's minions and the bleed from a Darius attack also have been found to work very well in combinations with Cassiopeia


Watch out if you are midding against these champions. Fizz has a strong utimate ability that can slow you and deal massive damage, but if you can shut him down pre level 6 you should be fine. Galio is one of the tankiest mids and his abilities have the ability to counter Cassiopeia. Diana uses her poke without spending much mana, so it is best to play defensive, go in when you see a chance, poke moderately, then when you get the chance with a jungler or your ult to go in for the kill. Watch out for LeBlanc because her abilities are OP and you need to play it safe. If she decides to try and turret dive (Which many do because of her passive which creates another LeBlanc at low health) use your ult to stun her and your Noxious Blast followed by Twin Fang combination.

Champions that Cassiopeia counters

Nunu & Willump
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Farming is very easy using Cassiopeia due to her Noxious Blast. However, make sure not to overpoke. If you poke too far, it puts you in the "danger zone" and vulnerable to ganks by the opposing jungler. You want to find the perfect mix where you play offensively but are cautious enough to be able to escape if needed.

Wards are always a great to prevent ganks. However, if you do not want to spend the money to purchase either Sight Ward or Sightstone, you could use miasma to check brush which gives you 7 seconds of vision of that brush. Make sure you are still cautious not to waste all of your mana, but to dominate the mid at the same time.
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Tips / Tricks / Things To Know

*Make sure that you don't max out Miasma first. So many people fall victim to that because they think that it is better to slow their enemies. However, in the end you will find that when you do this, you also get ganked much easier, and enemies don't walk through the big purple spot on the ground.

*Make sure to check your team's composition before choosing Cassiopeia because you may just find that she is not the best fit for that specific scenario.

*Make sure to make usage of Deadly Cadence by casting spells right after that first one. However, don't waste them if you don't need them.

*Make sure that Petrifying Gaze is used when as many enemies as possible are facing you. And, it can be used either offensively or defensively.

*Watch out for any ganks! Cassiopeia is squishy, and even though she can slow, you can find yourself dead if you get over confident. TO avoid this, you can place down Miasma to slow your enemies and do poison damage if being chased.

*Make sure that your enemy is poisoned before using Twin Fang because otherwise the cooldown might take awhile.

*Miasma-check brush before going into it late game. This can also be used to counter possible ganks early/mid game, and is a great strategy to scare off the enemy jungler.
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Hall Of Fame (Coming Soon)

This chapter will consist of sucessful results using this guide - Coming soon

Feel free to message me with any scores you get by using my guide!
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Summary & Credits

I hope you guys all enjoyed my guide! If you are looking for the queen of ability power, then make sure to try out Cassiopeia because if you use her right, then you will be unstoppable!

If you guys liked my guide, then make sure to vote it up, as well as send me any scores that you may get by using it so that I can add you to the Hall of Fame/Results page

Also, I am completely open to any constructive criticism that you may have, and open to any suggestions that you may want added into the guide. The following people have helped to make this guide possible:

ThaKinetic - many good points on things to change and helpful tips
IceCreamy - I would never know how to make the columns without your guide, and you played a huge role in the design of my guide.
WOMBO - you also had many good points and suggestions yo add to the guide, which made a much better build in the end.
jhoijhoi - Your guide on how to make a guide is what got me started, and none of this would have been possible without it.

Also, make sure to check out my other guides! Currently I have guides for the following characters:

P.S. I will probablly upgrade this guide a lot, so make sure to check back!
Last Edited ~ December 1, 2013

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