You aren't here 'cause of me

Pros + A lot of mobility + A lot of map pressence + Mastering is revarding + Good scaling + Really fun to play + Very rewarding when mastered + Really good sustain + Great team-fights + Huge 1-shot potential + Great pick finder + Lots of cc and aoe dmg Pyke mid is really good as a pick as he brings a lot to the table: mobility, a lot of cc, good teamfigts, lot's of damage, and he is really fun to play.

Cons - High learning curve - Susceptible to CC - Has some really hard matchups - Easy to mess up Pyke, even though he is really strong, has a lot of hard matchups and it is really easy to mess up..

SUMMONER SPELLS - FLASH: Flash is a great summoner spell overall, but what makes it a must is the fact that it enalbes some combos IGNITE: Helps you start your snowball, reduced healing is really usefull especially for you not to mess up your ult reset. TELEPORT: Don't take tp

Starting Items: Corrupting Potion might seem as a bit of an overkill with your passive, but what is wrong with that (+ it isn't tbh, and mana regen is really usefull).

Rushes: As you wave clear is quite bad, Tiamat is a must, and Mobility Boots should be rushed because we want that map pressence.

Core: These 3 items give you everything you need: enough damage, map ressence and a bit of tankyness. You should take Youmuu's Ghostblade first for that out of combat ms, than Duskblade of Draktharr and lastly Dead Man's Plate.

Item pool: -I usually after finishing my core items, go for Lord Dominik's Regards as it gives you a lot of dmg and armour pen, If their team has a lot of healing, go for Mortal Reminder instead.
-Go for Edge of Night when they have a lot of cc, you can't afford to be locked down.
- Spirit Visage: when you nead magic resist.
- Randuin's Omen: when you are threatened by crit-based champions
- Black Cleaver: More armour shreading, why not?
Elixirs: Elixir of Iron gives you 21 ad, and Elixir of Wrath gives you 30, so it isn't much of a difference; take yellow pot when they have a lot of cc, and take red pot if they don't.
-Don't forget Control Wards

#1 Usual: Corrupting Potion --> Tiamat + Mobility Boots --> Youmuu's Ghostblade --> Duskblade of Draktharr --> Dead Man's Plate --> Lord Dominik's Regards --> Edge of Night

#2 Tanky: Corrupting Potion --> Tiamat + Mobility Boots --> Dead Man's Plate --> Randuin's Omen --> Duskblade of Draktharr --> Youmuu's Ghostblade --> Thornmail

#3 Tanky with a normal start: Corrupting Potion --> Tiamat + Mobility Boots --> Youmuu's Ghostblade --> Duskblade of Draktharr --> Dead Man's Plate --> Randuin's Omen --> Thornmail

Domination
Dark Harvest- makes sure you scale well and snowball hard.
Sudden Impact- more dmg
Eyeball Collection- more dmg
Ultimate Hunter- you need your ult quite a lot.

Inspiration
Biscuit Delivery-sustain
Time Warp Tonic-sustain (and ms)
*note: Those new runes, as they aren't on live servers I haven't tested them yet, so i am not sure which should you take, and when should you take them, I chose those that will give you the most dmg as Pyke.