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Vayne, the Assassin
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Spells:
Flash
Exhaust
Ability Order
Night Hunter (PASSIVE)
Vayne Passive Ability
Introduction
The main focus of my masteries is on maximizing
Vayne's damage output. She is a ranged hero with quite good escape skills, so she does not need that many defense, but a little bit might not be wrong, so I also put some points in that.

I think there is no optimal build, it always depends on your opponents, your playstyle and the whole situation you are in. This item builds should only give you a basic direction, whereof you should probably differ from depending on the factors mentioned above.
This item is a really great choice for starting with
Vayne. It gives you damage, HP and life steal, which increases your harassing ability and your survivability at the beginning. I really recommand buying this item for most situations.
Buy this boots if the opponent team has a lot of stuns, slows and taunts. This item gives you better survivability in that case and additionally also a little magic resistance. This boots I normally pick for
Vayne.
This boots are hardly needed, but in some cases, where the opponents have high movement speed you might want to buy this kind of boots.
Trinity Force fits really well to
Vayne, because it increases your damage dealt after casting a spell by 50%. This passive ability really increases your damage output a lot, when using
Tumble and
Condemn frequently. Furthermore you also get HP, mana and movement speed.
This item helps you against tanks or HP stacking heroes.
Bloodthirster adds lots of damage and life steal to your attacks. It is really worth buying it as a ranged DPS if you feel your life gets low too easily.
If you need more damage, but survivability is no problem yet, get this item.
This item adds armor and attack damage. So if you think you get damaged by physical attacks too often, buy
Atma's Impaler.
Guardian Angel's passive is great, because lots of people then try to focus other heroes in team fights first, because they know you would be revived again, what is often a wrong decision, because you have very high damage in late game and can take out one by one. Additionally it also gives you a little armor and magic resistance, which also increases your survivability.
This item is quite good, if the enemy team does lots of magic damage. Consider buying
Force of Nature in this situation.
Start Items
Doran's Blade

This item is a really great choice for starting with

Boots
Mercury's Treads

Buy this boots if the opponent team has a lot of stuns, slows and taunts. This item gives you better survivability in that case and additionally also a little magic resistance. This boots I normally pick for

Boots of Swiftness

This boots are hardly needed, but in some cases, where the opponents have high movement speed you might want to buy this kind of boots.
Core Items
Trinity Force





Situational Items
Madred's Bloodrazor

This item helps you against tanks or HP stacking heroes.
The Bloodthirster


Infinity Edge

If you need more damage, but survivability is no problem yet, get this item.
Atma's Impaler

This item adds armor and attack damage. So if you think you get damaged by physical attacks too often, buy

Guardian Angel


Force of Nature

This item is quite good, if the enemy team does lots of magic damage. Consider buying

Night Hunter


Tumble



Silver Bolts

This skill increases your base damage dealt for every third consecutive attack.
Condemn

This skill is really great. You can use it for attacking to knock back an opponent, stun him when he hits an object and it additionally does lots of damage. This skill probably needs a little bit of exercising to get enemies stunned at the right time or only knocked back in dangerous situations, but if you are aware of that, it is just amazing and so much fun to use.
Final Hour




First Spell
Flash

This spell is always good for escaping dangerous situations or chasing enemies, if the opponent has not many life left and you would not get him killed otherwise.
Second Spell
The second spell really depends on your team and your personal preference.Exhaust

I really like

Ghost, Ignite





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