Hi guys!
It's my first full guide (before that guide I was doing only items build, without chapters etc.) I can't speak english very well, so sorry for mistakes :)

Pros:
- Very good mid and late game
- Pro in teamfights
- No mana
- Good escape system
- Impossible to gank
- Good sustain

Cons:
- Weak in early game
- Small base movement speed
- Long cooldown in early game

Heal - With all stacks fromTides of Blood and healing effects increase fromSPIRIT VISAGE it can heal 700+ hp!
Flash - Good to escaping or chasing enemies.
Ghost - Destiny of this spell is similar to flash's destiny.
Ignite - More dmg :) Good to use on adc to decrease life steal.

Masteries 0/9/21 is the best option for Vlad. In defense we take HP and HP regen. In utility we take more movement speed, CDR, Spell Vamp and experience.

SORCERER'S SHOES - The most popular boots for APC. Magic penetration = more DMG.
HEXTECH GUNBLADE - Spell Vamp is very important for Vladimir.
RYLAI'S CRYSTAL SCEPTER - Vladimir have only 1 slow, so passive of this item is necessary for him. It give you more HP and more DMG so this item is the best item for Vlad.
SPIRIT VISAGE - HP, MR, HP regen, CDR and increase your healing effects. All of these bonuses are good for Vlad.
ZHONYA'S HOURGLASS - AP give you more DMG, Armor give you more sustain. Perfect :)
RABADON'S DEATHCAP - For the end more AP :) Remember! - More AP mean more HP :)
ENCHANTMENT: ALACRITY - Vladimir is slow champion, so more movement speed is always good :)

BOOTS:
BOOTS OF SWIFTNESS - Vladimir is slow champion, so these boots are available for him.
IONIAN BOOTS OF LUCIDITY - With masteries andSPIRIT VISAGE we have 26% CDR, so we'll have full CDR if we'll buy these boots. It's available for champions with spellshield like Sivir to fast breake shield.
MERCURY'S TREADS - Good against strong AP opponent, or champion who has a lot of crowd control effects (ex. Leona)
NINJA TABI - Good against strong AD opponent.

DEFENSIVE ITEMS:
WARMOG'S ARMOR - Good for opponent who deal a lot of true DMG (ex. Cho' Gath)
RANDUIN'S OMEN - Good to help escape with slow of this item. A lot of hp and armor - Good against AD opponent.
GUARDIAN ANGEL - Good for AD and AP enemies. This passive... <3
TWIN SHADOWS - MR, AP, CC and movement speed. Good item - if you want to play more aggressive you can buy it instead ofSPIRIT VISAGE.

OFFENSIVE ITEMS:

DEATHFIRE GRASP- CDR and a lot of AP. Active of this item is good against tanks.
LIANDRY'S TORMENT - More HP and AP + Magic Pen. Available item, but not recomended.
SPIRIT OF THE SPECTRAL - Cheaper thanWILL OF THE ANCIDENTS, it gives you CDR less AP. I prefer WILL OF THE ANCIDENTS.
VOID SAFT - It give you 35% magic pen, but there are a loot of better items for Vladimir.

Greater Mark of Magic Penetration - Magic Penetration = more DMG.
Greater Seal of Armor - On start Vlad have only 12 armor!
Greater Glyph of Scaling Magic Resist - It will help us in late game.
Greater Quintessence of Spell Vamp - Spell Vamp is most important utility for Vlad.

You can see, that I don't take any AP runes. It makes Vlad's early game harder, but we will be better in late game :)

Crimson Pact - Every 40 points of bonus health gives Vladimir 1 ability power and every 1 point of ability power gives Vladimir 1.4 bonus health. These bonuses do not stack with themselves. - This passive give us more HP based on AP. With full build it's about 600 HP :)
Transfusion - Vladimir drains the lifeforce of his target, dealing 90 / 125 / 160 / 195 / 230 (+60% of ability power) magic damage and healing himself for 15 / 25 / 35 / 45 / 55 (+25% of ability power). - Our the best spell. On 1st level it have long cooldown (10 sec), but on 5th level it's ok :D (4 sec). It have good demage. With life steal and healing effects increas it can heal u a lot of HP :)
Sanguine Pool - Vladimir sinks into a pool of blood for 1.5 seconds, becoming untargetable, gaining 40% movement speed, and slowing enemies above him by 40% for .25 seconds. The slow duration is refreshed if enemies stay within the area of the pool. The movement speed bonus decays rapidly over the duration.

Vladmir deals 20 / 33.75 / 47.5 / 61.25 / 75 (+3.75% of bonus health) magic damage every half second to them and heals himself for 12.5% of the damage done. - It's very good escape system. You can avoid Karthus's, or lose Fizz's or Fiora's ult :)
Tides of Blood - Vladimir unleashes a torrent of blood dealing 60 / 85 / 110 / 135 / 160 (+45% of ability power) magic damage to nearby enemies.

Each cast gives him an Empowered stack (max 4), increasing his healing and regeneration by 4 / 5 / 6 / 7 / 8 % each. Additionally, his next Tides of Blood deals 25% more damage and costs 25% more Health per stack up to a maximum of 60 / 80 / 100 / 120 / 140 health and 120 / 180 / 240 / 300 / 360 (+45% of ability power) damage. - PRO farming system + healing effects increase :)
Hemoplague - Vladimir infects the target area with a virulent plague. Affected enemies take 12% increased damage for 5 seconds.

After 5 seconds, infected enemies take 150 / 250 / 350 (+70% of ability power) magic damage. - Use during teamfights and try to chase all enemies :)

Vladimir has PRO farming system, becauseTransfusion doesn't cost anything andTides of Blood can hit all enemies around you. When we haveHEXTECH REVOLVER we have 12% Spell Vamp + 6% from runes +3 from masteries = 19% Spell Vamp, so we can use Tides of Blood without any cost! :) In 20th minute you should have about 150 creeps. MINIMUM 100! If u puched your lane you can kill wolves.

You have 1 role in teamfight - focus the most squishy enemies, so ADC or APC. U have good sustain so you can play aggressive :) I have one good tactic - 1.Hemoplague, 2. Tides of Blood, 3. Transfusion, 4.ZHONYA'S HOURGLASS 5. Tides of Blood, 6. Transfusion. 7.Sanguine Pool, 8. Tides of Blood, 9. Transfusion and your enemy is dead. Now we can flash away :) If you are low HP you can useHeal.

Vladimir is champion with a lot of DMG and high sustain, so he can carry the game, if we can play him :) His sustain let him flash into teamfight, use ult, cast all spells and kill ADC :)