Miss Fortune synergizes extremely well with the Dark Harvest rune. This guide will help you make Sarah "Miss" Fortune the one-shot "assassin-like" ADC that she has the potential to be!

Broken Damage = Love Tap Passive + Duskblade Damage + Rapid Firecannon Auto Attack Damage + Dark Harvest Rune Damage (after collecting a soul) + I.E. Increased Crit Damage

I prefer to put my flash on D and heal on F for if I have to flash then use my ult.

-As soon as you get to lane from helping your Jungler leash, Double Up the low melee minions. These melee minions should be the perfect health to get all 3 if you leave to get to lane AS SOON AS your minions meet the enemy's minions. Try to auto the enemy ADC at least once before the next wave comes. You cannot engage and kill versus most ADC's at this level since you have one of the lowest base attack stats in the game in the ADC class.

-Now focus on getting the mage minions low enough to get the extra crit damage from them when you Q them. What do ADC's want? CS. What do you do when they try to get a last hit on a minion? You Q the minion in line with where they're heading.
Tip: Get the mage minions low to setup a potential Q onto the enemy ADC or Support then wait for the enemy ADC to get next to or touching these minions. Strut to the ADC with them thinking you'll auto attack them. They'll try to run away from you. Now Q the mage minion that is in line with the ADC. This won't work every time since they will get accustomed to this trick.
Tip: E the ADC while they're near the low mage minion wave to make it easier to get a Double Up on them from the mage minions.

-To maximize DPS during trades, you'll want to try this combo on the enemy ADC or Support: E, Auto Attack, Immediate Q (You can animation cancel your auto but if you aren't practiced enough you can actually cancel your auto attack), Immediate W after hearing her say "Ha" when she's in the Q animation, then 2-3 more auto attacks. This will actually have them at below 1/2 health and easily get them to use their potion. This isn't even considering what your Support is doing.

You have to get used to the extra Love Tap damage. Miss Fortune can clear a minion wave very fast by auto attacking various minions instead of just focusing one minion. If you get Doran's Blade instead of a Long Sword, make sure you're auto attacking as much as possible to get the full benefit from it's life steal and the life steal from the Domination runes.

-Setting up Q crits in team fights is nearly impossible even for extremely skilled Miss Fortune mains. Your main concern is to set up your E-R combo. Wait for someone to apply hard CC to the enemy team or right before they do to use your E then decide if your E is good enough to Ult into. (For example: You should E-R right before a well-aimed Nami Bubble catches the enemy ADC and/or squishy support instead of waiting until they are about the exit the bubble to maximize damage on the enemies. You should actually try to Q and/or auto attack before you do this to maximize damage.)
-Your passive is extremely important to keep applying to various enemies during fights. Try to switch between the squishy ADC, Mid, or Support in bunched up team fights all while your W ASPD bonus is up. Switching targets and applying your passive Love Tap to various enemies will allow you to have your W up sooner to reapply the ASPD bonus.

-Dark Harvest: Adds to your one-shot potential at all stages of the game. This extra damage even procs on your bounced-off Double Up so after getting a soul from a cannon minion in laning phase, get the mage minions to low hp then Double Up the enemy ADC or Support (preferably the ADC to tilt them off the face of the Earth).

-Taste of Blood: Extra Life Steal for team fights when all 5 of the enemy team tries to take out the major force that you are

-Eyeball Collection: Why not have a rune that gives you extra AD? Make sure to be the one to last hit enemy wards.

-Ravenous Hunter: YOUR ABILITIES NOW HEAL YOU SO WHY NOT TAKE THIS RUNE AS AN ADC WHO PRIMARILY DOES DAMAGE FROM YOUR ABILITIES? Your broken Q dmg... heals you. Your E slow... heals you. EVERY WAVE OF YOUR ULTIMATE NOW HEALS YOU (thank you Riot).


-Presence of Mind: You are a Mana Hog in laning phase. Whenever you level up, this gives you a chance to use your E slow for free to setup a double up onto the enemy ADC without them noticing. If you get level 2 before the enemy team, immediately get your E and use it to give your support an easier chance to CC the enemy ADC or Support.

-Coup de Grace: Just another way to bully the enemy ADC. When they run out of potions after you've been Doubling Up them over and over again, you'll start dealing even more damage to them (thanks Riot).