Kassadin is possibly Talon's easiest matchup. He has a horrible laning phase pre-6 due to his lack of mobility. The best tip I can give you is to try and end the game before he hits level 16, as he outscales you HARD.
Akali
Akali is pretty easy for Talon, especially after all her nerfs. Maxing Q into her ruins her day, and make sure to not spam your W while she is in her W unless you absolutely know where she is inside of it.
Karthus
Karthus' Q is super easy to dodge with mobis, and he is super immobile and squishy. Be careful of his ult though. Getting an early EoN is really good into Karthus.
Aurelion Sol
Talon negates a huge margin of Sol's damage due to the fact that he stays inside his starts to deal damage. Watch out for his stun and roams, and you should be fine.
Ekko
Ekko is a pretty easy matchup due to his meh laning phase. If he E's away from your second W, flash in his direction so your second W still hits for a free passive.
Gangplank
Gangplank is pretty squishy without items and his oranges are not that good against you. Just dodge his barrels and you will crush him.
Kayle
Kayle is similar to Kassadin in the sense to where she has a bad laning phase but an amazing late game. The thing that makes her slightly more annoying to deal with is the fact that she is ranged and she can go invulnerable.
Galio
Galio has always been an easy matchup for Talon, due to the fact that he is only tanky against AP. But after they removed his Flash + Taunt combo, it got even easier. His ult however is still decent at counteracting your roams, so be careful when he ults.
Corki
Corki has a pretty okay laning phase, but without his passive he has limited mobility, wait out his E when he uses it and then go all in.
Vel'Koz
Vel'Koz can deal a shit load of damage with the True damage from his passive. As long as you dodge his Q and E you should be fine.
Swain
Swain's E and Q can be annoying, but other than that he is pretty easy to lane against. Just save your combo for when his ult is on CD, as it makes him pretty tanky.
Twisted Fate
Twisted Fate has no disengage other than his gold card and has no mobility. Also, you can catch up super quickly when he ults. Watch out for his blue card, as it deals a ton of damage.
Veigar
Veigar has a super bad laning phase. The best thing to do against a Veigar is to dodge his E at all costs, and if you get caught inside of it, try and dodge his W.
Xerath
Xerath is a pretty easy matchup unless they are scripting or they are Zwag. As long as you move unpredictably, his skillshots are a piece of cake to dodge. Do not use your E while in vision, as it will make it super easy for him to land his stun and kill you.
Taliyah
Taliyah has very good waveclear and poke, along with good disengage with her E + W. Make sure to follow her when she roams, and E over her R when she traps you.
Ziggs
Ziggs is not very meta currently, but he is still very tedious to lane against due to his strong Q poke, waveclear from his E, and the fact that he can knock you away with his W. Make sure to get an early stopwatch or EoN to negate his ult damage.
Yasuo
Yasuo is a skill matchup. If he is good, his W will negate 80% of your damage and he will dodge every W you throw out with his E. Make sure to Q on him first so that it is easier to land your W, and don't engage when he has his tornado Q up. Tabis is good into him as well since his Q counts as a basic attack.
Yone
Yone is similar to Yasuo, but a little bit easier since he does not have a Wind Wall. When he E's in, make sure to dodge his Q's and try to focus him once he goes back to his original location, as he will be vulnerable. Dodge his R at all costs.
Zed
My favorite Talon matchup in the game, as this is 100% a skill matchup. The biggest tip in a Zed vs Talon lane is who ever ults first usually loses the fight.
Annie
Annie is really annoying for Talon due to her stun and her ability to last hit super easily. Do not engage when she has her passive up and punish her when she goes to get close to you for a Q.
Cassiopeia
Cassiopeia's poke is really bad for Talon, especially with no MR. Make sure to stay out of her W since you cannot E or Q while inside it and face away from her when you engage on her to stop her ult stun.
Katarina
Katarina is not a bad matchup for Talon, as your melee Q screws her up super hard. Stay away from daggers and try to predict where she will use her E for an easy passive proc.
Lissandra
Lissandra is not very meta right now due to her Q having such a long CD. Make sure to buy an early QSS and you should be fine.
Sylas
Sylas used to be a pretty hard matchup for Talon, but due to multiple nerfs including his E shield being removed, it got easier. Be careful when you E next to him, as it will make his second E super easy to hit.
Qiyana
Qiyana's multiple dashes make her super slippery, especially when in the jungle. Make sure to not stand too close to terrain so she doesn't get a good R off and stand behind minions to dodge her elemental Q's.
Jayce
Jayce is super annoying to fight due to him having 6 abilities and multiple disengages. Do not get hit by his accelerated Q, as it deals around 1/4 of your health if you're not careful.
Malzahar
Point and click suppression is cancerous to deal with. Make sure to buy an early QSS as the cc and damage from Malzahar's ult is insane. To get rid of his passive shield, use W or Tiamat on a wave so that it hits him, as it will catch him off guard.
Seraphine
Seraphine is similar to Lux in the sense to where she can shield your damage and she has really strong poke. I would try to bait out her echoed E before going in, and dodge her R at all costs.
Lux
Lux has a lot of burst potential with her Q, E, and R combo. Make sure to dodge her Q and you should be fine. Since her W was nerfed, she is even more squishy which makes it even easier to oneshot her.
Fizz
A bad Fizz beats a bad Talon, but a good Talon beats a good Fizz. Bait out his E, since when it is on CD it is easy to combo him. Make sure to dodge his ult at all costs, and you should be fine.
Ryze
Ryze used to be a bad matchup for Talon, but after the removal of his instant root and shield, this matchup got way easier. Make sure to stand away from minions so that his E doesn't bounce onto you, since his Q will deal a bunch of damage.
Viktor
Viktor has strong poke, but he has a very weak early game and has horrible mana issues without his Mythic item. Dodge his W and burst him once you hit your level 2 spike. Roaming is good too as he has really bad mobility.
Ahri
Ahri's crowd control and burst on top of her mobility makes her a rather annoying matchup. Make sure to stand away from the minion wave so that she cannot farm and poke at the same time and dodge her charm at all costs.
Brand
Brand is rarely picked mid, but he is still a pretty good counter to Talon. His damage is really hard to handle even with hexdrinker and his passive + Q will destroy you. Make sure to roam often and do not stand near minions when he ults.
Anivia
Anivia has a lot of cc and damage that makes it hard to lane against her. Her E when used on a crowd controlled target deals a huge amount of damage without MR, so dodging her Q is key. Always check to see if her passive is up before engaging, and remember that you can E over her wall, so use it unpredictably to catch her by surprise.
Neeko
Neeko is similar to Lux and Morgana in the sense that she will deal a lot of damage if she hits her root. Make sure to dodge her E, and remember that it travels even farther through minions. When you see her casting her R, E away if possible.
Rumble
Rumble has some of the most damage over time in the entire game. Get out of his Q and R asap and make sure to dodge his E poke. His W shield is pretty OP right now, so make sure to only go in when it is on CD.
Irelia
Irelia has huge amounts of damage, especially in teamfights with her ult. Make sure to dodge her E stun as it also causes her Q to reset. Do not combo while she is in her W, as it will negate a large margin of the damage.
Syndra
Syndra has huge amounts of burst with her R and a super long ranged stun that ruin Talon's day. She can interrupt your ranged Q with her E, making engaging difficult. Roaming is key here as she is super immobile and cannot keep up with you.
Morgana
Morgana is a really strong counter to assassins, and Talon is no different. Her binding lasts for over 2 seconds and her W deals a shit load of damage especially at low HP. Make sure to also get a QSS for her ult in teamfights, as the AoE stun will probably win her it.
Orianna
Orianna has some of the most poke in the game due to her Q + W spam. Make sure to always know where her ball is to prevent her from landing a good ult and go in when her E is on CD.
Zoe
CertainlyT's champion designs never fail to amaze me. Zoe has huge amounts of bursts especially when she lands her E + Q combo, which will most likely deal at least half your health. She can also steal summoners, which makes escaping her hard. She cannot keep up with your roams though, as without a summoner she is super immobile.
Heimerdinger
Heimerdinger is a very annoying matchup for Talon, but not an impossible one. Make sure to destroy his turrets and play safe. Bait his grenade and go for an all in, as he is very squishy.
LeBlanc
LeBlanc is a really bad matchup for Talon due to her insane burst potential. Make sure to dodge her E and don't stand too close to her when she Q's you.
Azir
After Talon's rework, Azir went from an average matchup to an extreme one in the blink of an eye. Talon can no longer negate his ult and soldiers with the removal of his old E, so now your best bet is to roam as he'll just poke you outta lane. Be careful of his Shurima Shuffle, as it is one of the strongest combos in the game.
Diana
Diana has some of the highest burst in the entire game. Watch out for her Q, as it makes her E able to be reset. Her shield absorbs a lot of damage if she has a lot of AP, which makes her also pretty tanky with it active.
Renekton
Renekton is one of the strongest lane bullies in the game, due to his stun, tanky ult, two dashes, and strong AoE damage. He will demolish you if you get too close to him, so your best bet is to roam, as his two dashes have a long CD so he cannot keep up very well.
Malphite
Malphite is another super hard matchup for Talon because unless he screws up, you will never kill him. Do NOT stand close to him once he hits 6 and try to stay out of lane as much as you can.
Alistar
Alistar is one of my favorite supports to play with due to his high amounts of crowd control, which makes Talon able to pull off a free combo.
Zyra
Even though she is not very tanky, I still love Zyra for her crazy amounts of cc and burst. She is also good with Talon as she won't make his team full AD.
Sejuani
Sejuani is an early ganker, which is always good for an early game monster like Talon. Her cc is good too.
Zac
Similar to Sejuani, he has great amounts of cc and he has really oppressive ganks.
Renekton
Renekton and Talon are not bad with each other due to them both being amazing early game. You both can control objectives and are super oppressive. The only problem is that you both fall off late game.
Rengar
Talon does not synergize very will with other AD assassins due to him usually making the team full AD if there is another one on the team. Rengar in particular provides little cc for Talon, and his early ganks are not the greatest unless Talon can bait for him.
Thank you for reading the small little Talon guide I made. I will update it with every patch, and I will also consider adding more details such as combos, laning phase, etc.
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[Season 11] - Coldsong's Talon Guide!
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