Twisted Fate is a very cool champ and everyone should play him. This guide is written primarily for those poor people who called mid in ranked, and then some jackass first pick took their lane. Have no fear, you shall be able to play your favourite champion at bot lane, and get more fed than your mid laner ;). And don't forget to report them after the game

We covered that above, if you got the hybrid penetration runes, just take them instead of magic pen.

Standard AP, be ready to go mid, if your teammate is afk.

So for our items we want to start off with the support item and some pots. When you first come back, buy sightstone or upgrade your support item if you don't have the money. Don't buy wards, they will put you behind in terms of items(use your sightstone/trinket instead).

Your core items are sheen and athenes. Then try to upgrade sheen into Lich bane. For boots i would go sorcerer's shoes or mobis, you decide what's better. Finish it up with rabadons and void staff for extra damage. You can also go for zhonya or rylay's depending on the matchup.
And sell your support item after a while, i forgot to mention that. Or you can sell sighstone.
When i think about it, you should ALWAYS sell that sightstone, because the upgraded spellthief gives some pretty good stats.

Harras with your autoattacks all the time, and try to hit them wild cards when they go in for cs. If they engage, stun their adc and then q-auto-auto?. Try to get as much gold as possible from that support item, you are going to have to carry them noobs. Wild cards are great for pushing the minion waves, so use them if you are stuck under your tower. Be carefull of bad trades cuz TF has no sustain. If you are getting ganked, use your cc on the enemy jungler.

So this is where tf shines. You should have your sheen by now, so you can push towers pretty fast. Use this to your advantage. Try to gank mid with your ult, and coordinate with your jungler. Take as many kills as possible.

You got it this far? By now you should have gotten a few items so gg. Protect your backline noobs in teamfights with the gold card, or use your aoe slow if they group. Since you can't go in with your ult (you are probably too weak), use it to check objectives instead.