Hello :D, this is my first guide and it's in my favorite champion! Twitch!

Overview of this guide.
Twitch is an amazing ADC, he has one of the best carry potential of any ADC in the whole game, maybe even greater than Kai'Sa. He's a sorta hybrid between an ADC and an assassin, since late you can use your Ambush to position your self in a team fight with a Runaan's Hurricane you can tear up a team in a matter of seconds. There's a reason there are so many highlights of Twitch opening up on a baron play and coming out with a Penta kill.

Before you go hating on me for having Lethal Tempo, hear me out. Lethal Tempo not only gives you an amazing team fighting tool late game but also gives you really good damage in lane. Although the damage in lane might not be as good as Press the Attack or doesn't give as much sustain as Fleet Footwork, It has a much better late game for when you need to put your team on your back and carry. Now I'm not saying only go Lethal Tempo, You need to be adaptive in your runes in whether it's going to be either A. a hard lane where it goes late or B. An easy lane that ends early, In most lanes where you lose outright like a Caitlyn and a Zyra you will take Fleet Footwork, in a game where you stomp early like against Ashe/ Vayne take press (unless the Vayne has an actual good support then go Lethal Tempo to scale with her).

A standard ADC starting item, buy if you know you're going to be aggressive in lane and constantly using the extra AD to your advantage

Another standard ADC item after the Heal nerfs, ADC health nerfs, and ADC regen nerfs, An overall great item if you're going to be passive in lane and wait for the late to start scaling.

A component of Blade of the Ruined King, it gives you really good sustain and damage, Try to usually first back to this component.

Recurve Another component for Blade of the Ruined King, Buy this if you are super far ahead, because of the attack speed from this and boot components. Usually though, back for Bilgewater Cutlass.