Heal I use Heal very seldom because Vayne is easy to be killed only in early game, so I try just not to die :D


Flash I use flash to jump through walls and to run, when I'm about to die and the enemy is trying to catch me.


Surge 35%(45% if you use my masteries) bonus Att. Speed for 14 secounds, more than you need to score a double kill, perfect for early and late game.


Teleport I use it only when i'm playing with AIs


Exhaust Good for escaping and chasing, one of my favourite but I don't use it a lot because of the Cooldown


Ignite Possible

Every other spell is not recommended for Vayne

Pros
-Good damage
-Good Attack speed
-Perfect spells for carry
-Stun and Stelth
-Ranged
-True Damage
Cons
-Weak in early game
-Slow
-Easy to be killed
-Difficult

The items i take are very usual and common for AD Carries, and i think i don't have to explain a lot about them.
The core is :

You should start with Doran's Blade , then take Boots, the best choise for early game are Berserker's Greaves. After that take Dagger and complete Zeal. The next step is the Bloodthirster, buy Vampiric Scepter for better creeping and when you have enough gold go for the rest, then complete your Phantom Dancer. Now you can start killing the other team, because you are strong enough to score a double kill witout help (:

Anti-tank Build
I hate playing vs Tanks because they are very strong, but with Silver Bolts and 55% chance to do 250% Damage and Madred's Bloodrazors, you have preaty nice DMG,Att. Speed and Penetration.



Best Survivability:
Description is not nessesey

Trinity Force Vayne
The Lantern will help you to do a perfect Condemn, you need just to put a ward in the grass and when you are ready just press "E" and score a perfect Condemn with stun and double damage and it's almost imposible to miss that kill. Trinity Force will help you a lot with it's 150% DMG after a spell and 25% chance to slow the enemy.

My Build


The last item depends on the teams. If my team needs Healt Regen, Life steal and Att. Speed I take
If the other team is very fast and I need more HP I take
If I need more DMG I take secound or giving also Att. Speed and Armor.

First of all it's stupid to buy runes if you don't have 20 level.
My runes are chosen for early game playing, when I need critical strike for harrasing and combining with Tumble, and Att. Speed for combining with Silver Bolts
The Runes choice depends on your playing stile, it's mistake to take runes for Mana, Mana regen, Healt Regen, Healt, Dodge etc. thing that you don't need. You can find more information about Rune Choice here Vindictive Vayne Build