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Gragas, drinking powah!
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Since I started LoL (long time ago, june 2010), I saw that the characters I played the best were the AP. I loved mid lane, and I improved my skills more and more. This guide is for Gragas, but I will probably make also guides for Swain and Lux.
Usually, I choose Greater Seal of Scaling Ability Power because it gives really nice ability power at the end of the game, but i also recommend Greater Seal of Scaling Mana Regeneration for the mana reg.
For glyphs, I take Greater Glyph of Ability Power, for the extra ap. I take Greater Quintessence of Ability Power for the same reason.
I upgrade the Boots to Sorcerer's Shoes as soon as possible. If you are getting CC'd a lot, then Mercury's Treads are also a really nice item.
I start building the Rod of Ages by the catalyst the protector. Extra HP and mana, and also the regeneration when lvl up. This item increases a lot your durability at lane. I finish the Rod of Ages, then go to Rabadon's Deathcap, then Rylai's Crystal Scepter, Banshee's Veil and finally, I usually take a Guardian Angel, but a Abyssal Mask is also a really nice item.
The skill sequence is really easy to follow, Explosive Cask> Barrel Roll> Body Slam> Drunken Rage. Be sure of using Drunken Rage whenever possible for the extra AD for lasthitting and restoring your mana in lane. It is also good for getting down towers. The combo of Explosive Cask-> Ignite-> Barrel Roll-> Body Slam is really powerful, and your opponents life will get down in just a moment, if not died. Also, try to use Drunken Rage before using Body Slam for the extra damage, Body Slam scales with AP and also with ->AD<-.
Flash is a relly good spell (if not the best of the game) for every character. Gragas also has Body Slam, so whit Flash and Body Slam you have a nice escape and chasing method. You can pass over two walls at the same time, you can tower dive easily, put out of range of tower, etc.
Ignite is a really nice extra dmg. Added to your combo, it will be devastating. It is also really good for champs who heal a lot such as Vladimir, Dr. Mundo and Swain.
Alternative summoner spells:
Ghost : The alternative to Flash, I use it with Lux, and it works also well with Gragas. If you chose this spell, remember to change the mastery tree at the utility part.
Teleport : It's ok, as you go to mid lane. But I prefer Ghost or Flash over Teleport.
Not to choose:
Clarity: Gragas is mana hungry, yes, but you have your Drunken Rage and a lot of mana reg, so why do you want clarity? You don't need it.
Fortify: I've seen lots of Gragas with this spell. I don't recommend it, if someone is taking it, you must not be that one. Let it to the tank, you are the AP carry.