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This lane is very simple for Zed. No mobility and low damage early. This lane is very easy to play out as you can kill him over and over.
Kog'Maw
Kog'maw is an amazing match up for Zed. Just like Karthus he has no mobility and even less damage than Karthus. Most of his damage is avoidable as well, therefore making this lane super easy.
Aurelion Sol
Sol is close to the easiest match up for Zed. When playing against him do not be afraid to swap to W, and start auto attacking him rapidly. A all in at level three is a strong play from the Zed player, and will most likely result in a kill. Stay as close as you can to him to avoid taking damage from his W.
Varus
Varus is a great match up for Zed in most stages of the game. He is immobile and has CC on a long cool down. Bully him in lane and get some distance between him in after trades to avoid constant auto attack poking
Kha'Zix
You won't see this as a pick very often, but can still be played in the mid lane. You can out damage him early by simply standing by your minions because he can't get the isolation passive off. Most important thing is to be wary of his ult. Your ult still applies but it effectively gives you a shorter period of time to hit him.
Vel'Koz
This is one of the simpler match ups for Zed. Stay on him as his damage won't be too much of an issue because he is all skillshots. He is immobile with little CC.Dodge E and the match up is in your favor.
Zyra
Zyra is the squishiest champion in League of legends. Your rotation at level 3, if hit properly, will deal 60% of her health. It is very important to either fast swap or preemptively W to dodge her R. Her E is very slow so make sure to W out of it.
Akali
Akali is a pretty simple match up with you dealing more damage than her most of the game. Buy a pink ward early for better results.
Ezreal
Ezreal has large amounts of poke at all stages of the game. If you dodge correctly the lane should be pretty simple. You out damage him most of the match so kills on him should be easy. When ulting onto him save W to follow his E.
Kassadin
Kassadin is a simple match up for Zed as he is only good against AP. You can kill him early because he doesn't have any mobility pre 6. After 6 every time he uses ult to farm go on the aggressive and kill him.
Teemo
You won't see Teemo that often. You can out damage him in most points of the game. He has a blind, but generally auto attacks won't be your main source of damage.
Veigar
Veigar is a match up in favor of Zed. Your early damage and bullying is far superior. Veigar will be trying to play safe and farm up for the late game. Constantly stay on him and go for all-ins. His E is easily dodgeable so make sure to do so. Pick up a late game Banshee's veil.
Xerath
Xerath is a great match up for Zed. His immobility is key for Zed players to get on him. Besides dodging skillshots it is most important to fast swap or flash out of ult because he can throw stun behind him.
Taliyah
Taliyah is fairly simple to lane against. Zed is able to out damage her for most of the game. The most important thing to dodge is her E, which will knock you away, after you dodge that Taliyah will have to use a summoner spell or die.
Anivia
Anivia is a good match up for Zed. Aniva's Q is a very slow skill shot and can be dodged easily. Try not to take too much harass early and the match up should be rather simple.
Fizz
The Fizz match up is one of the easier match ups. Look to trade before he hits level 3 and before he hits 6 because of his power spike. His E can nullify your R so it is important to fight around that. Dodging his R can get rid of most of his damage.
Galio
Galio isn't a champion you will see very often. In the case that you find one, he can be beat easily due to his scaling being MR based. The thing to look out for is that his ult will make you not able to use abilities, which is a lot of Zed's damage.
Lux
Lux is a good match up. Lux has no escape so it is easy to get the kill if you dodge her Q. Lux does have the ability to wave clear early, so building your first long sword into a Ravenous Hydra can meet her wave clear.
Ziggs
Ziggs is a match up of who can bully who. Constantly be on the move because his Q is on a very low cool down. Ziggs does not have a direct escape although he does have W. Make sure to dodge his ult with R to negate a lot of his damage.
Corki
Corki is seen as a flex pick and could be played middle lane. Corki will auto attack you every chance he gets, so a doran's shield isn't a bad choice for a starting item. All ins are generally pretty easy because he has no CC.
Jayce
Jayce is a champion that can have a lot of his damage dodged easily. You have more damage than him if you all in him, but you will not beat him in the poke game. Stay behind your minions as best as you can to avoid his damage.
Nidalee
Nidalee's damage is scary compared to other AP assassins. Her Q can be dodged rather easily due to it being a slow skill shot. Be careful when auto attack trading cause her abilities do a lot of damage. Space her out and you should be fine.
Annie
Annie is a so-so match up for Zed. Annie has the CC and damage to beat Zed, but it's up to the Zed player to dodge what you can. Doran's shield is recommended against her due to her constantly auto attacking you with her large range.
Brand
Brand is a okay match up for Zed. Harass as much as possible and dodge his W. Fast swapping after you ult is important to dodging his CC.
Heimerdinger
Heimerdinger is a decent match up. He will push you in very hard, but your passive helps you with getting pushed in. His turrets do a lot of damage so make sure to be in the turret field for as short of a period of time as possible.
Katarina
Katarina is a skill match up when both players hit 6. You can trade as much as you want before 6 because her damage is really low. Most Kats start cloth armor which helps with their poor laning, if they do not, abuse that and trade constantly. Most of her R damage can be dodged with the invincibility on R.
Kennen
Kennen is a skill match up because a lot of his damage is dodgeable. His ult does a surprising amount of damage so it is best to all-in him early before 6. His poke is good so it's best to get some distance between him.
Morgana
Morgana is a pick you don't see much but she isn't bad against Zed. Her ult needs to be avoided so make sure to throw down a W after swapping back to R. Her laning isn't the best so be sure to take advantage of her. If she uses Q in lane make sure to take that time to trade.
Twisted Fate
Twisted fate is rated a 2 threat level in lane and 6 out of lane. He doesn't have an escape, so killing him isn't that big of an issue. It is very important to note that TF's gold card can get canceled midair with R. Late game TF with be using his gold card on you so make sure to buy a Quick Silver Sash.
Viktor
Viktor's damage can catch you off guard. It is important that you walk left to right rather than backwards and forwards because he has good range on his E. When ulting make sure to W directly after it to insure you don't get stunned when he places it below him.
Ahri
Ahri is among one of the harder match ups but still can be handled well. Harass as much as possible before 6, and be careful when ulting as she can charm behind her and CC you. She also has great mobilty making her harder to kill the later the game goes on. Fast swapping is important here.
Cassiopeia
Cassiopeia is a skill based match up. Stay far away from her and farm with Q. When you hit 6 you can go for the kill just make sure to dodge her R. You can do this by back clicking or W,R dodge.
Ekko
Ekko is a match up that you have to know your damage on Zed. The main issue with Ekko is that he doesn't die after he hits 6 unless he is out of position because his ghost is in a bad place. Trade with Ekko early, as you can win almost all trades. Stop trading after he has two stacks on you so he doesn't chunk your health bar.
Karma
Karma is a pick you don't see very often, but is actually a decent pick into Zed. Her disengage is above average compared to other mid laners. She also has a shield for good survivability. Her poke isn't bad and she has good CC. It is best to trade early and focus on damaging her.
LeBlanc
This is a pure skill match up. In this lane the person that gets a single kill over the other snowballs very hard. The most important thing to remember in this match up is in early laning to Q after she W's forward. By doing this in lane you trade close to the same damage every time. Also ulting when she W's can dodge most of her damage.
Malzahar
This lane isn't very favored towards Zed. Malzahar has okay poke in lane, but his biggest counter to Zed is his R. A Quick Silver Sash is recommended as a third item in this match up so you don't keep dying late game. Trade with him early and you can come out on top. If you hit 6 before him pull the trigger.
Orianna
Orianna used to be a better match up before the ult change. Doran's shield is a good start against her because she will be constantly auto attacking you. Her auto attacks do extra damage so you have to stay far enough for her not to auto attack. Remember that she has a shield and CC when you all in so play accordingly.
Quinn
Quinn is a match up that requires you to be passive until power spikes. You can't win trades because of her blind and her auto attack damage. Use 6 to go aggressive. Recommend a Doran's shield start against early game Quinn.
Syndra
Syndra is a skill based match up. A lot of the lane depends on how good the Syndra is. Her low cool downs will make you get poked out of lane fast. Always look to get trades in between cool downs (which is a small period of time). Her E is dodgeable with W or R.
Talon
Talon is a skill based lane. Early harass is very essential because he most likely will be starting flask. Talon has better scaling than you in lane so pick your fights carefully and dodge key abilities with W or R. Talons like to max W so dodging that is most of his damage.
Urgot
Urgot is a laner you will not be put up against in many cases, which is nice because he isn't that bad of a pick against Zed. He has great poke in lane and will most likely start cloth armor or flask. He is immobile to an extent because his R hurts your R immensely. It is best to try to fight him before level two then ask for ganks because he is immobile.
Vladimir
Vladimir's sustain early is a big issue and only gets worse. Keep in mind that his W costs a lot of health to use and is on a long cool down. Poke him with Q early and attempt to snowball. If you do force a kill you can out scale him.
Riven
Riven is a skill match up that requires the Zed to dodge a lot of abilities. Early game she can out trade you so it is best to find the fights you know you can win. Good to note that her 3rd Q, W, and R can all be dodged.
Azir
This match up requires a lot of practice to come out on top. You will be poked constantly in the lane. Attempting to trade back is very difficult, so all-ins are more effective. Dodging his R with ult or w is very essential.
Yasuo
This lane is very tough for Zed. Most of this difficulty depends on the Yasuo and how the Zed reacts to his play. Yasuo will start E first and out damage you with Q and E. You start to grab the advantage at 6 but if you die early the lane is snowballed. The same goes for Zed if he gets the lead early. Time Q right and make sure to pop his shield before trading or all-ining. Dodging tornado is more than just dodging a knock up, you dodge a lot of his damage too.
Zilean
Zilean isn't a pick you will be seeing often which is good because he isn't a bad pick against Zed. It is very important that you dodge his stun with W. The worst part of this match up is his R which you always have to keep in mind when playing against him. Ask for ganks so you can lock him down.
Irelia
Irelia and bruisers in general are tough match ups for Zed. It's best to farm with Q and ask for ganks. All-ins will not swing your way because of her sustain and CC so it's best to just sit back and farm.
Ryze
Ryze is a very hard match up. Most Ryzes will start cloth armor and will sustain heavily with good damage and CC. It is recommended that you play very safe and ask for ganks. After he gets frozen heart it is more worth it to roam.
Cho'Gath
Tanks are Zed's weakness, Cho is no exception. Ganks are needed to win this match up, and try to only farm with abilities. Try not to get to close to him because he has a lot of CC early to shut you down. A BOTRK is needed first in the match up.
Diana
Diana is one of Zed's counter picks. Diana should take W first, out damage you, and survive early with the shield it grants. If a Diana takes Q first attempt to trade as much as possible with auto attacks. Ganks are important in this match up and to force fights that you know you can win.
Lissandra
Lissandra is counter pick against Zed and requires you to play really safe against her. She has great CC with W and R and an escape with E. Her R can also be used on her to make her invincible and gain a small amount of health. Diving her is very hard due to all of the things previously mentioned. Roaming is recommended in this match up.
Lulu
Lulu is a really hard lane match up. Between the good damage, shields, and the lifesaving R you are going to have a tough time. It's best to farm up and ask for ganks because she has no escape. Recommend that you roam.
Zed
This lane is all skill and knowledge (and ganks). It is very important to time your abilities right so they can't be dodged. You have a slightly higher advantage when ulting second so you can avoid some, if not all, his damage but this is not always true.
Kayle
Kayle counters Zed in a lot of ways. Zed only has one ranged ability, so she can harass Zed early. Your all-ins late will not be effective either because of her ult. In lane if you do manage to get her 60% or less then use aggressive W's and delay your R until she uses hers. She can't win in an auto attack battle so she will use it eventually.
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