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Karthus Build Guides, Runes and Items

Karthus The Deathsinger

Find the best Karthus build guides for League of Legends S12 Patch 12.12. The MOBAFire community works hard to keep their LoL builds and guides updated, and will help you craft the best Karthus build for the S12 meta. Learn more about Karthus' abilities, skins, or even ask your own questions to the community!

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Karthus Build & Runes

If you're looking for the best rune build for Karthus we've got you covered. Below you can find the best items and runes to build for Karthus, as determined by calculations of thousands of Plat+ League of Legends games. If you are already familiar with how to play Karthus this is a great resource to quickly get a good rune selection for Patch 12.12. However, if you are a new Karthus player we highly recommend reading through some of the guides above to learn why this build is strong on Karthus!

Patch 12.12: 312465 matches scanned * Each section of the build is rated independently of the others

Karthus's Runes

Karthus's Best Runes 51%

Win Rate 1143 Games

  • 1
  • 2
  • 3
Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Second Best

Karthus's 2nd Best Runes 46%

Win Rate 1642 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Treasure Hunter
Treasure Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Third Best

Karthus's 3rd Best Runes 50%

Win Rate 924 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Treasure Hunter
Treasure Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Coup de Grace
Coup de Grace

Karthus's Summoner Spells

Karthus's Best Summoner Spells 45%

Win Rate 5581 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Summoner Spells 49%

Win Rate 4887 Games

Exhaust Smite

Third Best

Karthus's 3rd Best Summoner Spells 52%

Win Rate 143 Games

Exhaust Flash

Karthus's Starters

Karthus's Best Starter Items 46%

Win Rate 4496 Games

  • 1
  • 2
  • 3

Trinket

Karthus's Best Trinket 47%

Win Rate 7472 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Trinket 46%

Win Rate 2404 Games

Stealth Ward

Third Best

Karthus's 3rd Best Trinket 47%

Win Rate 945 Games

Farsight Alteration
Don’t forget
to Buy Wards

Karthus's Ability Order

Karthus's Best Ability Order 66%

Win Rate 2032 Games

  • 1
  • 2
Patch 11.20: 494917 matches scanned * Each section of the build is rated independently of the others

Karthus's Runes

Karthus's Best Runes 55%

Win Rate 418 Games

  • 1
  • 2
  • 3
Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Taste of Blood
Taste of Blood
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Second Best

Karthus's 2nd Best Runes 57%

Win Rate 134 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Taste of Blood
Taste of Blood
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ravenous Hunter
Ravenous Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Third Best

Karthus's 3rd Best Runes 54%

Win Rate 330 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Karthus's Summoner Spells

Karthus's Best Summoner Spells 53%

Win Rate 1592 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Summoner Spells 53%

Win Rate 168 Games

Flash Teleport

Third Best

Karthus's 3rd Best Summoner Spells 52%

Win Rate 109 Games

Flash Heal

Karthus's Starters

Karthus's Best Starter Items 71%

Win Rate 28 Games

  • 1
  • 2
! Small Sample Size Warning * There is either not a lot of games played on this champion or the builds vary greatly, we have provided the top build but it does not have a high confidence rating so use your own discretion.

Trinket

Karthus's Best Trinket 55%

Win Rate 1137 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Trinket 51%

Win Rate 697 Games

Stealth Ward

Third Best

Karthus's 3rd Best Trinket 54%

Win Rate 137 Games

Oracle Lens
Don’t forget
to Buy Wards

Karthus's Ability Order

Karthus's Best Ability Order 100%

Win Rate 1 Games

  • 1
! Small Sample Size Warning * There is either not a lot of games played on this champion or the builds vary greatly, we have provided the top build but it does not have a high confidence rating so use your own discretion.
Patch 12.12: 312469 matches scanned * Each section of the build is rated independently of the others

Karthus's Runes

Karthus's Best Runes 54%

Win Rate 74 Games

  • 1
  • 2
  • 3
Inspiration
LoL Path: Inspiration
LoL Rune: First Strike
First Strike
LoL Rune: Magical Footwear
Magical Footwear
LoL Rune: Future's Market
Future's Market
LoL Rune: Cosmic Insight
Cosmic Insight

Domination
LoL Path: Domination
LoL Rune: Ultimate Hunter
Ultimate Hunter
LoL Rune: Eyeball Collection
Eyeball Collection

Second Best

Karthus's 2nd Best Runes 52%

Win Rate 71 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Third Best

Karthus's 3rd Best Runes 51%

Win Rate 132 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Taste of Blood
Taste of Blood
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Coup de Grace
Coup de Grace

Karthus's Summoner Spells

Karthus's Best Summoner Spells 51%

Win Rate 1187 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Summoner Spells 47%

Win Rate 688 Games

Flash Teleport

Third Best

Karthus's 3rd Best Summoner Spells 48%

Win Rate 230 Games

Flash Ignite

Karthus's Starters

Karthus's Best Starter Items 49%

Win Rate 1604 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Starter Items 52%

Win Rate 129 Games

Corrupting Potion

Third Best

Karthus's 3rd Best Starter Items 49%

Win Rate 387 Games

Health Potion Tear of the Goddess

Trinket

Karthus's Best Trinket 48%

Win Rate 1253 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Trinket 50%

Win Rate 967 Games

Farsight Alteration

Third Best

Karthus's 3rd Best Trinket 43%

Win Rate 209 Games

Oracle Lens
Don’t forget
to Buy Wards

Karthus's Ability Order

Karthus's Best Ability Order 64%

Win Rate 225 Games

  • 1
  • 2

Karthus Counters

Learn 's counters and discover matchups where they have an advantage! When you're starting a game of League of Legends you should always keep in mind if you'll be at an advantage or disadvantage against your opponent, so you can know whether to bully them or play safe. You can find detailed breakdowns of each matchup on CounterStats, and you can also check out some Karthus guides to see how to build and play against other champions you may find yourself up against!


This counter data is for Karthus Jungle in Plat+ games. The percent shown is the enemy champion's counter rating against Karthus. Counter rating is our own statistic that factors in counter kills, overall kills, early lead ratio, comeback ratio, and win percent to give the whole picture of that champion's effectiveness as a counter pick.

Karthus Skins

Karthus' Abilities

Questions About Karthus

League of Legends Champions:

Teamfight Tactics Guide