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Karthus Build Guides, Runes and Items

Karthus The Deathsinger

Find the best Karthus build guides for League of Legends S12 Patch 12.9. The MOBAFire community works hard to keep their LoL builds and guides updated, and will help you craft the best Karthus build for the S12 meta. Learn more about Karthus' abilities, skins, or even ask your own questions to the community!

Karthus Build & Runes

If you're looking for the best rune build for Karthus we've got you covered. Below you can find the best items and runes to build for Karthus, as determined by calculations of thousands of Plat+ League of Legends games. If you are already familiar with how to play Karthus this is a great resource to quickly get a good rune selection for Patch 12.9. However, if you are a new Karthus player we highly recommend reading through some of the guides above to learn why this build is strong on Karthus!

Patch 12.8: 513624 matches scanned * Each section of the build is rated independently of the others

Karthus's Runes

Karthus's Best Runes 49%

Win Rate 5289 Games

  • 1
  • 2
  • 3
Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Second Best

Karthus's 2nd Best Runes 48%

Win Rate 3498 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Treasure Hunter
Treasure Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Third Best

Karthus's 3rd Best Runes 49%

Win Rate 2159 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Coup de Grace
Coup de Grace

Karthus's Summoner Spells

Karthus's Best Summoner Spells 49%

Win Rate 14422 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Summoner Spells 47%

Win Rate 13240 Games

Flash Smite

Third Best

Karthus's 3rd Best Summoner Spells 55%

Win Rate 256 Games

Exhaust Flash

Karthus's Starters

Karthus's Best Starter Items 48%

Win Rate 12679 Games

  • 1
  • 2
  • 3

Trinket

Karthus's Best Trinket 48%

Win Rate 19978 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Trinket 47%

Win Rate 6009 Games

Stealth Ward

Third Best

Karthus's 3rd Best Trinket 47%

Win Rate 2423 Games

Farsight Alteration
Don’t forget
to Buy Wards

Karthus's Ability Order

Karthus's Best Ability Order 64%

Win Rate 5816 Games

  • 1
  • 2
  • 3
Patch 11.20: 494917 matches scanned * Each section of the build is rated independently of the others

Karthus's Runes

Karthus's Best Runes 55%

Win Rate 418 Games

  • 1
  • 2
  • 3
Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Taste of Blood
Taste of Blood
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Second Best

Karthus's 2nd Best Runes 57%

Win Rate 134 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Taste of Blood
Taste of Blood
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ravenous Hunter
Ravenous Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Third Best

Karthus's 3rd Best Runes 54%

Win Rate 330 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Karthus's Summoner Spells

Karthus's Best Summoner Spells 53%

Win Rate 1592 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Summoner Spells 53%

Win Rate 168 Games

Flash Teleport

Third Best

Karthus's 3rd Best Summoner Spells 52%

Win Rate 109 Games

Flash Heal

Karthus's Starters

Karthus's Best Starter Items 71%

Win Rate 28 Games

  • 1
  • 2
! Small Sample Size Warning * There is either not a lot of games played on this champion or the builds vary greatly, we have provided the top build but it does not have a high confidence rating so use your own discretion.

Trinket

Karthus's Best Trinket 55%

Win Rate 1137 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Trinket 51%

Win Rate 697 Games

Stealth Ward

Third Best

Karthus's 3rd Best Trinket 54%

Win Rate 137 Games

Oracle Lens
Don’t forget
to Buy Wards

Karthus's Ability Order

Karthus's Best Ability Order 100%

Win Rate 1 Games

  • 1
! Small Sample Size Warning * There is either not a lot of games played on this champion or the builds vary greatly, we have provided the top build but it does not have a high confidence rating so use your own discretion.
Patch 12.8: 513624 matches scanned * Each section of the build is rated independently of the others

Karthus's Runes

Karthus's Best Runes 58%

Win Rate 172 Games

  • 1
  • 2
  • 3
Inspiration
LoL Path: Inspiration
LoL Rune: First Strike
First Strike
LoL Rune: Magical Footwear
Magical Footwear
LoL Rune: Future's Market
Future's Market
LoL Rune: Cosmic Insight
Cosmic Insight

Domination
LoL Path: Domination
LoL Rune: Ultimate Hunter
Ultimate Hunter
LoL Rune: Eyeball Collection
Eyeball Collection

Second Best

Karthus's 2nd Best Runes 58%

Win Rate 114 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Taste of Blood
Taste of Blood
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Coup de Grace
Coup de Grace

Third Best

Karthus's 3rd Best Runes 54%

Win Rate 243 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Taste of Blood
Taste of Blood
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Karthus's Summoner Spells

Karthus's Best Summoner Spells 53%

Win Rate 1972 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Summoner Spells 50%

Win Rate 906 Games

Flash Teleport

Third Best

Karthus's 3rd Best Summoner Spells 53%

Win Rate 379 Games

Flash Ignite

Karthus's Starters

Karthus's Best Starter Items 53%

Win Rate 2523 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Starter Items 51%

Win Rate 564 Games

Health Potion Tear of the Goddess

Third Best

Karthus's 3rd Best Starter Items 53%

Win Rate 246 Games

Corrupting Potion

Trinket

Karthus's Best Trinket 50%

Win Rate 2029 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Trinket 54%

Win Rate 1432 Games

Farsight Alteration

Third Best

Karthus's 3rd Best Trinket 54%

Win Rate 302 Games

Oracle Lens
Don’t forget
to Buy Wards

Karthus's Ability Order

Karthus's Best Ability Order 65%

Win Rate 390 Games

  • 1
  • 2

Karthus Counters

Learn 's counters and discover matchups where they have an advantage! When you're starting a game of League of Legends you should always keep in mind if you'll be at an advantage or disadvantage against your opponent, so you can know whether to bully them or play safe. You can find detailed breakdowns of each matchup on CounterStats, and you can also check out some Karthus guides to see how to build and play against other champions you may find yourself up against!


This counter data is for Karthus Jungle in Plat+ games. The percent shown is the enemy champion's counter rating against Karthus. Counter rating is our own statistic that factors in counter kills, overall kills, early lead ratio, comeback ratio, and win percent to give the whole picture of that champion's effectiveness as a counter pick.

Karthus Skins

Karthus' Abilities

Questions About Karthus

League of Legends Champions:

Teamfight Tactics Guide