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Miss Supportune Guide
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What the fuck am I looking at here
On your first recall, you should aim to get Sightstone and Frostfang. Frostfang if you have <800 gold, Sightstone for early wards on dragon, Frostfang and Boots If you have 825 gold, are winning lane hard enough that you don't need to ward for bush control and can rely on your adc to ward the river bush since warding dragon is inadequate for detecting ganks.
Ionian Boots of Lucidity are your go-to boots. They let you spam E more, which in turn grants more damage than Sorcerer's Shoes would.
Ruby Sightstone and Frost Queen's Claim should be brought as late as possible, after Rabadon's even. Both of these items are really, really bad. Ruby Sightstone grants you the ability to place one extra ward before each recall in exchange for 400 gold. You also need to get an extra Ruby Crystal. 1. You don't build health. You do not scale with health. You are not meant to tank. This is not a tank build. Health is nice, but it's not an objective. 2. You can only place 3 wards on the map at any time. If you could place 5, it would have merit. You can't. Frost Queen's Claim on the other hand grants you an active and 10 AP in exchange for 545 gold. It also lets you take farm without locking you out of expending its charges for 12 seconds and requires you purchase a Fiendish Codex. Unlike the Ruby Crystal, you like the Fiendish Codex, but Frost Queen's Claim gives you half the AP of an Amplifying Tome for 110 gold more in exchange for an active with a similar range and effect to your E, except on a cooldown almost 10 times higher. The damage is negligible; the primary use of the active is its slow, and seeing as how your primary damage spell (on a low cooldown) does exactly that, I don't see the point. Frostfang has all the gold generation and free extra damage of its upgraded counterpart.
Liandry's Anguish is the first item you want to get after getting Frostfang, Sightstone, and picking up boots. Make it Rain works extremely well with Liandry's, shredding off 7% of the enemy champion's maximum health with a single tick and 13% if they stand in Make it Rain for the full duration.
With only Liandry's and Frostfang, excluding magic resist, runes and masteries, a max rank Make It Rain will deal 577 damage to a level 9 Veigar with no health items. This is equivalent to Veigar's max rank Baleful Strike (Q) with 579 AP with the same exclusions.
Lich Bane is a really good item on Miss Fortune. Your Q counts as an auto-attack, setting off and triggering Lich Bane's effect. Your W, both it's passive and it's active encourages auto attacks even without Q, so overall this is the last item besides Deathcap to round out your build. I take Liandry's first because her primary damage is in her E. While it's not a bad item in the slightest, it gets the short end of the stick when it comes to building Miss Supportune differently, so if you want any of the alternatives, replace this. (Though the situations where, you'd likely build them before or after Liandry's)
"What's this? A third AP item before Rabadon's Deathcap? Pure blasphemy!"
Yeah, well, you're going to have to make some calls. I normally either pause Lich Bane at Sheen for the spellblade passive, grab a Needlessly Large Rod and then wait until I can buy Rabadon's, or just skip Lich Bane, leaving it for after. Either way, you're not going to have enough item slots for something. If it's your personal preference, you could work towards finishing your Frost Queen's Claim while you still have the free item slot so that you don't need to wait until 1335 gold after finishing Lich Bane.
Anything in the bonus section except for the Elixir of Sorcery, feel free to grab whenever, at your discretion. Greater Vision Totem Should generally be gotten if you didn't buy a vision ward during laning phase, as buying it, placing one, then switching to the upgraded red trinket will save you 25 gold as opposed to buying the vision ward. Elixir of Sorcery should generally only be gotten when every single other item (even Ruby Sightstone) is finished.
Sorcerer's Shoes are a matter of playstyle; they will usually give you less damage than Ionian Boots of Lucidity would. The thing is, they provide more burst damage, and can bring out more damage if the enemy team is picking up lots of magic resist. The problem here is that you already do a lot of % health damage, already have a magic penetration item in Liandry's, and everyone but tanks normally don't let you react to the building of said magic resist with your boots, since you generally want to pick up boots before finishing Liandry's. Maybe if an AP champion on your team is getting a lot of early kills, you can predict enemies to build magic resist, but otherwise, only take these if your playstyle relies on burst.
Mobility Boots, for doubling your passive.
It's a matter of preference. Your W won't restore the effect, and unlike Strut, you lose it for attacking as well. Still, specialization=synergy, and you'll both get to lane pretty fast as well as make escaping pretty hard. (as long as you don't take minion aggro) I don't recommend these in any situation, but if you like them, they aren't the worst option.
Morellonomicon should really only be gotten if the enemy team has a heal-heavy composition. By heal-heavy, I mean three or more champions that utilize heavy healing (not just life steal) regularly. Soraka can count as two. It's not that this is inherently a bad item, it's just that Miss Fortune synergizes really well with the items listed.
Zhonya's Hourglass likewise should really only be gotten if the enemy team is heavily counteracted by it and/or mildly counteracted by it and is ad-heavy. Unlike Morellonomicon where you'd like to build it before or after Liandry's for the sake of hindering healing, you'd more likely want to build this before or after Rabadon's, unless the problem you're building this for is immediate, in your lane. (Double AD carry botlane and a Karthus for example)
Enchantment: Homeguard, unlike everything else in this list of alternate options, isn't inferior to its alternative besides highly situational circumstances. Enchantment: Alacrity Will let you dodge more and move faster outside of base, Homeguard will let you get to lane faster. Generally speaking you're better off with Alacrity when your team is winning and Homeguard when your team is losing, but Alacrity will provide more dodging, chasing, running and roaming capability either way and Homeguard faster travel. It's a matter of preference.