Cassiopeia
Build Guide by RezoneVerified
💀[NEW SEASON 15] CASSIOPEIA - The POISON Queen of Midlane ☠ 💀
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Recommended Items
Runes: Conqueror
1
2
Precision
Resolve
+9 Adaptive (5.4 AD or 9 AP)
+9 Adaptive (5.4 AD or 9 AP)
+10% Tenacity/Slow Resist
Spells:
1
2
Flash
Ignite
Items
Ability Order
Serpentine Grace (PASSIVE)
Cassiopeia Passive Ability
Threats & Synergies
Extreme
Major
Even
Minor
Tiny
None
Low
Ok
Strong
Ideal
Heimerdinger
Ideal
Strong
Ok
Low
None

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How is it going guys! My name is Rezone and I'm a Master Tier Midlane main. I peaked at 270 LP Master Tier this Season and have 4.5 Million Mastery Points on ![]() I was the BEST HEIMERDINGER EUW in Season 7 and I'm best known for inventing the Holy Trinity of Tilt build on ![]() ![]() ![]() ![]()
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FLASH![]() |
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IGNITE![]() ![]() ![]() ![]() ![]() |
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TELEPORT![]() ![]() ![]() ![]() |

Conqueror |
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★ ![]() ![]() |
Presence of Mind |
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★ ![]() ![]() ![]() |
Legend: Haste |
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★ ![]() |
Coup de Grace |
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★ ![]() |
Overgrowth |
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★ ![]() |
Conditioning |
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★ ![]() |

✦ ![]() Your core item on ![]() ![]() ![]() |
✦ ![]() Another core item for ![]() |
✦ ![]() With ![]() ![]() ![]() ![]() |
✦ ![]() Increasing our overall ability power by 35%, while providing an extra 120AP. This item increases your burst exponentially, and despite the hefty price tag, is more than worth it if you're ahead or need some insane burst. |
✦ ![]() This item is fantastic vs healers such as ![]() ![]() ![]() |
✦ ![]() If the enemy team is tanky, or building a lot of magic resist, ![]() |
✦ ![]() If you're ahead in lane and decide to purchase ![]() ![]() |
✦ ![]() This item is like ![]() ![]() ![]() |
✦ ![]() The best choice as a 3rd buy...whats better than poison? FIREY POISN, dealing damage with abilities causes the enemies to burn 1% maximum health magic damage per second for 3 seconds,.. This absolutely shreds down enemies and tanks, and synergises well with ![]() |
✦ ![]() Rod on Cassio can work well if you are wanting to scale into the late game, this combined with Liandries and Seraphs, you become tanky with a huge mana pool. ![]() ![]() ![]() |

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Serpentine Grace (Passive) |
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- The movement speed from Serpentine Grace is worth 48 gold per level, up to a maximum of 864 gold at level 18.
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Noxious Blast (Q) TARGET RANGE: 850 EFFECT RADIUS: 75 COST: 50 / 60 / 70 / 80 / 90 mana COOLDOWN: 3.5s |
After a 0.4-second delay, ![]() ![]() ![]() |
Noxious Blast uses quick casting by default.
- Bonus Movement Speed: 30 / 35 / 40 / 45 / 50%
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Miasma (Q) TARGET RANGE: 700 EFFECT RADIUS: 160 COST: 70 / 80 / 90 / 100 / 110 COOLDOWN: 24 / 22 / 20 / 18 / 16s |
![]() Debilitating Poison deals magic damage to enemies standing upon it every second, also grounding them and applying a slow that decays over the area's duration. |
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Twin Fang (Q) RANGE: 700 COST: 50 mana COOLDOWN: 0.75 |
![]() ![]() If the target is poisoned, ![]() ![]() |
Twin Fang's bonus damage and healing will also trigger on the following Poison:
Poison Trail,
Noxious Trap,
Toxic Shot and
Deadly Venom.
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Petrifying Gaze (Q) EFFECT RADIUS: 825 ANGLE: 80° COST: 100 mana COOLDOWN: 120 / 100 / 80 |
After a brief delay, ![]() Enemies facing ![]() |
Petrifying Gaze's target direction will change if
Cassiopeia's facing direction changes during the cast time (i.e. through knockbacks).
- The facing direction of champions whose abilities/animations cause them to lock their facing or spin is always the direction they are moving in. For abilities that cause the champion to spin in place (e.g.
Death Lotus) it will factor the direction they were facing on cast.

Early - Mid Game












When you get




Mid - Late Game






Focus on helping out with objectives as much as possible, you can shred through the Dragons, and the changes to them in Season 10 make them all the more important and impactful.





Thanks for reading my
Cassiopeia guide and I really hope you can take some of this information and apply it to your ranked games! Please drop me a comment, and let me know if there's anything I can improve on. I hope you can pop by any of my social media's and say hi! Feel free to check out any of my other midlane champion guides, and I hope you enjoy them just as much.


- 29/12/2019 - Published Guide.
- 17/11/2020 - Updated for preseason.
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