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You can make really good trades with him, try to bait his ult.
Annie
Can make even trades, and pokes you when you try to end the trade. Wait till 6 and after she uses her stun.
Akali
Usually banned, but if played against you mid, you'd like to force out her shroud. If she dives you can use e to stun.
Xerath
Out trades you hard, wouldn't recommend trying to go aggro on him without your jungler. Don't let him get any kills from you, or a shutdown, those can give Xerath a comeback.
Ahri
Very good poke, don't let her charm you our you'd get bursted. If you don't build some mr, its the death of you. Other than that you would be fine.
Anivia
Pyke's ult does not reset on anivia's passive anymore (I believe), which makes a huge counter. She has good poke, which is something that counters Pyke in the early game/laning phase. Then again if she is against a shoved wave, you can't do much. Make sure to clear as quickly as possible and ask for ganks whenever there is an opening.
Azir
His ult is ineffective against your ult because it pushes you away, yet if you cast ult and it hits him you end up going back to him. Deny his cs by going aggro. Keep out for enemy junglers if you do this.
Brand
Very effective against Pyke, if he can land a full combo, your dead or you'll be forced to recall losing cs and exp. Try to make efficient trades against him. Ask for ganks when possible.
Aurelion Sol
Force him out of lane by going aggro when he pushes. He can poke you simply with his stars that orbit him.
Diana
You destroy her in any way possible, but don't go all in, she can force you back into the turrent. Go in at 6, it is when its most efficient, and a quick locked kill.
Ekko
Force a trade at him when he misses his q. If Ekko misses his q at you, he is very vulnerable to damage, but don't go all in for the most, you never know if he could make an outplay.
Cassiopeia
Don't want to do a trade with her, because when moving back, she will poke you to your death, or to your tower.
Fizz
I've fought against many fizzes before. If you want to beat him, try to get him to waste his w on your e so you can land your ult. Other than that if you should be fine.
LeBlanc
Deals tons of damage, out trades you, forces you out of lane with a simple combo. Can dodge your ult, and your whole combo.
Neeko
As of patch 8.24, she is not yet nerfed, making her super deadly. She can bait you, lets say she can pretend to be a low hp varus recalling, then you ult it, but shes actually full hp. Beware of her ult and root, with it's 130% ap scaling, you would not like to be in that mess.
Zoe
My experience with Zoe players as Pyke Mid were simple. Just dodge her e, and your fine. If you can't seem to dodge them and keep getting bursted, rush a hex or spirit.
Vladimir
Dangerous, can heal massively, waste your ult, dodge it with his invulnerability. A threat to you and your team. You should get a hexdrinker, or an excutioner's calling.
Talon
Simply counterable, all you need to do to beat him in lane after he uses all his mana since he doesn't have the best mana sustain in lane.
Katarina
You can cancel her ult, make her dash into your e, has almost no way to out-heal your ult execute.
Yasuo
Ziggs
Can take your tower even when your behind, other than that you can easily kill him if you manage to land everything. You can also dodge his ult simply with either your w or e.
Veigar
Even when behind, he can easily catch up to your lead. His passive scales infinitely, and his ult is a great execute for his stacks. You want your team to focus him before he can do some major damage.
Nocturne
Beware for him in the Jungle. If he ganks you and your are shoving wave, you can be dead in a matter of time.
Kayn
Another jungler you want to watch out for.
Karthus
Beware, even after you kill him, his passive which lets him cast any of his spells (not summoner-spells) which can poke you and even kill you after you killed him. His ult is something you can't stop when hes in his death passive, so if he casts it when he is targetable, you can cancel it and put it on cooldown.
Graves
Has simple ganks that can kill you. Beware if he ganks your lane, you don't want him to shut you down, or let your laner get the first kill in the mid lane.
Alistar
If he can get the ideal 3-5 man knockup, you can easily win a teamfight as long as you have a team to back you up.
Neeko
Her ult and your ult, can easily kill the weakest of teams who didn't build, mr or armor.
Gragas
Depends on his skill level, and when he ults.
Zilean
When you go aggressive all in, a Zilean support can save your life.
Tahm Kench
Another support that can save you when you go all in.
Synergies
IdealStrongOkLowNone
Alistar
If he can get the ideal 3-5 man knockup, you can easily win a teamfight as long as you have a team to back you up.
Neeko
Her ult and your ult, can easily kill the weakest of teams who didn't build, mr or armor.
Gragas
Depends on his skill level, and when he ults.
Zilean
When you go aggressive all in, a Zilean support can save your life.
Tahm Kench
Another support that can save you when you go all in.
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