Hello Summoners, this is a guide for the highest damage overall statistically. Please read every single note as they have useful information. If you have any questions or feed back let me know. And if you found this guide effective please vote.

I believe building your runes around early game is superior to scaling runes. If your opponent's runes are all about late game for example scaling ap glyphs. You have a tremendous advantage over him early game.And your mistakes will be less punishing. You get your early game stats from Runes, and late game stats from items, same goes with Masteries.

These are the only Marks I would touch for AP Teemo.
Marks
x9 Greater Mark of Attack Speed Makes your early game trading very strong with Toxic Shot and it's helpful to last hit minions if your timings are off.

x9 Greater Mark of Magic Penetration These are the best marks for overall damage, but makes you much weaker early game.

These are the only Seals I recommend for AP Teemo.
Seals
x9 Greater Seal of Scaling Health Very effective seal works against true damage, attack damage, ability power. Scaling health seals got buffed the most and armor got nerfed.

x9 Greater Seal of Armor Are stronger vs AD from level 1-6 then Greater Seal of Scaling Health becomes better.

These are the only Glyphs I recommend for AP Teemo
Glyphs
x6 Greater Glyph of Scaling Cooldown Reduction Your full build has 30% CDR and with these 6 Glyphs caps you at 40% CDR. Feel free to use x9 Scaling CDR Glyphs since most of the time you won't get level 18 before the match ends and you'll get more cdr quicker.

x9 Greater Glyph of Ability Power Early levels Greater Glyph of Ability Power is even with Greater Glyph of Magic Resist. But mid game Greater Glyph of Magic Resist will become better since it reduces damage by a percent.

x9 Greater Glyph of Magic Resist Beats Greater Glyph of Ability Power mid game.

x9 Greater Glyph of Magic Penetration Will do more damage than Greater Glyph of Ability Power mid game. And once you get Sorcerer's Shoes, Liandry's Torment Greater Glyph of Magic Penetration will be even more effective.

x9 Greater Glyph of Scaling Ability Power Don't get these. Greater Glyph of Magic Penetration does more damage in every level.

These are the only Quintessence's I would get for AP Teemo
Quintessences
x3 Greater Quintessence of Ability Power These are the strongest Quints to get these are required to have for early game pressure.

x3 Greater Quintessence of Magic Penetration These Quints would give the most damage overall but Greater Quintessence of Ability Power Is more beneficial since it's such a big damage increase early game.

Ferocity
Fury > Sorcery Because 4% attack speed provides a much stronger early game than sorcery. For example let's say you Q someone and hit them for 80 damage, that's only 2 extra damage from Sorcery. And on top of that let's say my Shroom hits someone for total of 500 damage that's only 10 damage.

Fresh Blood > Feast Every 30 seconds with feast you get 20 health. Every 30 seconds with Fresh Blood you can deal 50 damage. So you can see which one is more effective. Feast is better for Melee champs I believe.

Vampirism > Natural Talent Absolutely take Vampirism over Natural Talent. Vampirism is one of the only ways to get spell vamp unless you sacrifice a quint. You can get 190 health before laning phase ends, now try doing that with Natural Talent. Not only that it only gets stronger since it scales by percent.

Double Edged Sword > Bounty Hunter Battle Trance I believe Double Edged Sword is the best overall for Teemo since his Q Blinding Dart gives him immunity to basic attacks temporarlly, which makes his trading better and having 5% extra damage off the bat is great. However versus mages Battle Trance Should perform better since their basic attacks aren't a big deal.

Piercing Thoughts Because your primary damage is magic damage, don't take Battering Blows for early game damage lol.

Deathfire Touch Will give the most overall damage. However Thunderlord's Decree is an excellent choice for 1v1 and bursting.

Cunning

Savagery > Wanderer Savagery is superior to Wanderer I believe Wanderer is the worst mastery to get lol. I've tested Wanderer and with x3 Speed quints, tier 2 boots you only get to lane from base .8 seconds quicker. GARBAGE.

Secret Stash > Assassin Secret Stash is superior to Assassin especially since it's a small map and most likely someone's going to be in your lane. Since you're getting a refillable potion Secret Stash becomes even more valuable.

Merciless > Meditation Merciless is a great mastery for Teemo.Which gives 5% more Damage for Deathfire Touch , Noxious Trap, Liandry's TormentIt's really the difference of killing someone or not. And Teemo shouldn't have mana problems if you manage his spells.

Greenfather's Gift > Dangerous Game Both are great if you want a stronger lane take Greenfather's Gift which overall is better than Dangerous Game . If you wan't to do cute plays get Dangerous Game .

Precision > Intelligence Precision will give the most overall damage and makes you scale harder. It's superior over Intelligence

Executioner's Calling I know this looks bad to get but it's absolutely necessary versus Warwick and someone with lots of healing Dr. Mundo Sona Etc. I highly don't recommend building Morellonomicon getting Nashor's Tooth and Liandry's Torment is much more beneficial. I would get Nashor's tooth then Liandry's Torment then instead of upgrading to Sorc Boots get Executioner's Calling instead.

Quicksilver Sash This is the best item to buy against Malzahar and Warwick. Just like Executioner's Calling get this after Nashor's Tooth/Liandry's. And delay Sorcerer's Shoes. If you're ahead you can also buy this item for defense.

Guardian Angel This a great item for team fights you can sell your Sorcerer's Shoes for it late game. It can be the difference of winning or losing.

Banshee's Veil This is a great item to buy if you're having trouble vs bursty champion's like LeBlanc Annie Lux. Typically good to buy it after core items. Or if you're ahead, sometimes the best offense is defense.

Moonflair Spellblade Yes I know this item looks bad but it's highly underrated in my opinion. It's great versus a mix of damage and bunch of mini stuns like Riven, Annie etc. 50 AP, 50 Armor, 50 MR and 35% tenacity that's a great deal for 2500g. It's really the jack of all trades. I would get this later in the game, after your core items ( Nashor's Tooth, Liandry's Torment, Sorcerer's Shoes. Delay this item if they're starting to get magic resist. And get Void Staff first.

Getting 10% cdr from Glyphs is a pretty big deal late game. Blinding Dart cooldown goes from 5.6 seconds to 4.8 seconds. And Noxious Traprecharges every 12 seconds instead of 14. Which results in almost 1 extra Noxious Trap per minute.

Teemo TIPS
1. Prioritize placing Noxious Traps to prevent ganks over aggressive shrooms.
2. Place Noxious Traps where enemies would retreat (typically just outside enemy minion path but only do it if it's safe and they don't see it.)
3. You can use your shroom to get the Lich Bane effect. Prioritize using Q,W first for proc, unless your R will hit them.
4. If someone is rooted, stunned, taunted or just cc'd place your Noxious Trap on top of them.
5. USE YOUR PASSIVE if you're waiting in lane and nothing else to do you can stand still for and wait for the enemy laner to come to get that bonus attack speed and catch him by suprise. You can do this while he's in lane too waiting to last hit minions.
6. Blinding Dart Teemo's Q is resets your auto attack so try your best to auto attack first then Q.
7. Noxious Traps You can bounce your shrooms in team fights to force your enemies to position differently.
8. Blinding Dart Save your Q in lane facing melee/ranged AD unless you're really ahead of them. For example facing Tryndamere you only use Q when he E's on you. But use it late as possible before he hits you.
9. Noxious Trap If you kill your laner you should push the lane quick as you can by placing a shroom on the creeps so your enemy laner will completely miss a wave. He will lose gold and experience.

MORE TIPS ARE COMING