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Kassadin will outscale you and you have practically no kill pressure by yourself.
Lucian
Lucian lost a lot of solo lane power but he still claps you, just with less damage by himself
Aurelion Sol
You will rarely see this champion mid but he outranges you and has the mobility to make quick escapes, can also follow up on your roams very easily.
Ahri
This matchup goes even for Galio, probably can't have kill pressure on her at level six but you can outroam (careful she can cancel your E midway with her charm)
Akali
Akali is one of the best matchups for Galio, not only has the champion been nerfed quite a lot she also does not hurt you and you can reveal her in her stealth with your W or E, can also follow up on her roams quite easily, the only bad part is if she has conqueror then you can't duel, but other than that you should be fine.
Aatrox
You will quite possibly never find him mid but I have, you can't duel him he runs conqueror and ignite, early bramble and tabs is key, under turret farming and roaming is the way to win.
Anivia
I can't remember the last time I won against an Anivia, I don't know what it is but everytime this champ is in the game it's a loss.
Annie
Will Q you off cooldown but you should be able to tank her, early merc treads is very good.
Azir
Azir is also a rare pick but he will outrange you and it's very hard to gank for, don't get caught with his ult flinging you under his turret. Earlier mercs/swifties is also good
Brand
Brands early damage will make you lose trades and they usually run ignite, just make sure to stand behind minions to avoid the stun if you are already on fire from his burn.
Corki
Corki has become a hard matchup lately, it's him poking you down a lot of the time and you can hardly get in range.
Diana
Diana is one of my favorite matchups, she will tickle you with her combo if played right with aftershock and merc treads and you'll usually win trades against her. During teamfights look to ult the teammate she is focusing.
Ekko
A good matchup for galio he usually can't hurt you much but watch out for his stun it will cancel your W
Fizz
Galio is Fizz's hardest counter but one misplay and you could quite possibly die and it's gg mid, when he Q's and it on top of you make sure to E backwards into your own turret to either force Fizz to get chunked or he uses his E and you safely dash in your turrets direction.
Heimerdinger
I rarely see him mid but it's easy to just afk farm and outroam a heimerdinger. You will run a risk dahsing in to him if he has turrets up though
Irelia
Irelia is also one of the hardest matchups, paired with conqueror and blade of the ruined king she can eaisly 100 to 0 you with ignite too. She also hard outsustains you with corrupting and a yuumi heal on every Q lol.
Jayce
Jayce is a hardish matchup, second wind with seekers and tabs and you should be good to go, just watch out his early combos hurt more than they look.
Karma
Can barely touch you just afk farm and try to outroam her
Karthus
Will barely see him mid but it's super easy to deal with him and super easily gankable if flashless.
Katarina
Katarina matchup is even, very similar to fizz one mistake and it could be gg mid, AD kat is not something to sneeze at and can hurt a lot with kraken and bork. Very easy follow on her roams.
LeBlanc
Hard to play aggressive into and hard to gank but you can outfarm and follow on her roams
Lissandra
Lissandra is an easy matchup, second wind with verdan barrier and she doesn't hurt with her Q's and it's very easy to follow on her roams.
Lux
Lux is easy matchup very similar to Lissandra. You can allow yourself to get rooted in the stepback of your E cast and the dash will still go through.
Malzahar
Malzahar is simple, you can remove his spellshield with rocketbelt off CD and is easily gankable once spellshield is down.
Neeko
Neeko is an easy matchup you can survive her poke with mercs first back and follow up on her roams, your teamfight is better than hers.
Orianna
Even matchup, can't take very long fights or she will end up winning it. Also runs phase rush so it's hard to pick her.
Pantheon
Pantheon is a simple lane, don't die early to his combo and get seeker tabs, if your quick and have the anticipation you can cancel his stun with your E
Qiyana
Similar to Pantheon, early seekers tabs and you can beat her. Just watch out when your low she can crit on abilites similar to Pantheon.
Rumble
Rumble is easy pickings, can tank his Q poke decently and can actually outrade him if played right.
Ryze
Ryze outscales but can be bullied in lane unlike Kassadin.
Seraphine
Every time I see seraphine mid she's out of mana after 4 min of laning. Very similar to Lux the only problem is she heals and outsustains you.
Sylas
This is my personal favorite matchup if you can cancel his W and avoid getting lashed by his E with your E you can win lane easily. Is usually out of mana after a couple of headbangs on the keyboard if he doesn't have corrupting pot
Syndra
Syndra is early mercs and you can avoid her poke. Just watch out she can push you back after your dash and so you can't catchup with her. also some of them run phase rush so they'll outrun you no matter what.
Twisted Fate
Even matchup, he gets more gold from farming but you can out trade him, his roams are quicker and easier than yours though so you have to anticipate them.
Veigar
Veigar doesn't have the damage to solokill you but his cage will stop your dash so you have to be careful.
Vel'Koz
Similar to Veigar the only problem is he has true damage so your shield and mr wont stop him from killing you.
Viktor
Viktor outscales and runs liandrys so your shield will take longer to refresh, if you engage on him he can throw his W down and stun and he does quite a lot of damage at lvl 6 for a scaling mage as well.
Vladimir
Vladimir will outscale but is easier to out trade out roam and gank once blood pool is down. Can bully early. Just watch out for giving him an early lead if he has ignite and dark seal
Xerath
A matchup I like to play against a lot, pokes similar to lux, do not stand in the middle of the wave when he charges up Q because he wants to hit both, force him to choose between you or the wave. The only issue is if you have fights going on bot and top he can ult from mid but if you're quick you can cancel it to give side lanes breathing room.
Yasuo
Even matchup, if he runs fleet he out sustains and if he runs conqueror he out trades. One mistake and it might be gg mid. Most yasuo's play like kamikazes though so is easily gankable. Early steelcaps and seekers, bramble is viable as well.
Yone
Similar to Yasuo, has a free cleanse on his E if he times it and casts it when you taunt or attempt to knock him up, early steelcaps and seekers. Bramble is viable too
Zed
Zed is a hard matchup he can poke without you getting near him he hard wins at lvl 6 or if he has conqueror, one mistake and it might be gg mid. Chances you die are very hard. This is the champ I ban mid.
Ziggs
You can outsustain his poke during teamfights look for where his ult is landing. Just can't get a good combo on him because of his W
Zilean
Won't see him often but hard to gank with his movement speed and his revive on ult. Afk farming is good.
Zoe
Zoe isn't that tough of a matchup you can survive her poke but a combo will chunk you, mercs is good and outroaming is good as well. Just watch out when using active items or summoner spells she can pick those up.
Talon
Talon has become an easier over time but he still has the highest base MR in the game. Seekers early and match his roams when you can. Don't contest early levels and certainly don't try to extend fights with past 6
The most basic of combos is Justice Punch into Shield of Durand(Must be held down for taunt time and damage to increase) which will then set up for an easy Winds of War Colossal Smash chunk damage. After this you back out and wait for cooldowns to come back up since Galio is as good as a siege minion without abilites up. You don't always have to land Justice Punch to trade sometimes you have to just use it as a gap closer.
Combo with R
After you've used Hero's Entrance on an ally you'll land where your ally was when you first casted it so make sure you use it when they're in the middle of the enemy team or being attacked. It's a great ultimate to counter champions like Diana or Ekko. After landing if the enemy team is near where you landed you're gonna wanna charge up a Shield of Durand for a big taunt. If you manage to hit anyone set up Winds of War into a Justice Punch and a Colossal Smash to finish it off, by then you should get the follow up from either the ally you ulted on or the rest of your team.
Quick combo
When wanting to make a quick combo on melee champs or to make it out of vision in Brush to do big damage you can aim for a Shield of Durand(the cast of W will not be seen in Brush similar to Sion's Decimating Smash. Once you land the taunt that will set up for a good Winds of War and then you can cast your Justice Punch backwards if you're right on top of the enemy to make sure it lands a lot quicker and won't give them as much reaction time and then Colossal Smash to finish it off. If you have runes like Aftershock and Shield Bash it will give you a little extra on your combo. Additionally, you can always use Everfrost since it fits in well at any point in the combination to make sure your champion remains where you want them to be.
Little tricks to watch out for
Watch out when you cast Galio's E ( Justice Punch)Near walls, this will make the ability possibly clip the wall when you're backed up into the wall making is cancel and go on cooldown, essentially wasting the ability.
Shield Bash gives you additional bonus Armor and Magic Resist when Shield of Durand's passive shield is active, and will keep giving you the additional resistances as long as the shield stay on, Shield Bash's damage has a cooldown of 8 seconds.
Galio is a champ you pick to have permament mid priority you have full clear backline of caster with Winds of War and Colossal Smash at level 4 if you have an Amplifying Tome, otherwise they will need an extra auto or you can finish them off with Justice Punch's little damage, otherwise wait for level 5 for an additional point in Q.
Once you're level 6 and have Hero's Entrance and a comfortable matchup you should be able to push in your opponent and hover towards bot or top to either look for a ultimate gank (Top laners that are easy to gank with Hero's Entrance include Camille Irelia Darius Wukong Renekton Riven.) These top laners are very easy to gank for and will give you an easier time to do so.
Supports that are easy to gank for (Because realistically you won't look to ult the adc if you're looking for an aggressive gank) include Nautilus Thresh Pyke Seraphine Leona. If your mid laner is missing always ping it and you should ALWAYS have a Control Ward in the river bushes, place it on the side that has an objective alive, if no objective is alive always place it botside. This way you can see if your enemy midlaner is rotating and you can follow up on it.
Thank you for taking the time to read the guide I made and learn more about Galio mid and what works best for him from my experience of playing and my 1.4M points on him. If there's anything you think I can improve upon or typos that I missed please let me know.
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