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Cassiopeia Build Guide by WaffleWarrior

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League of Legends Build Guide Author WaffleWarrior

Cassiopeia: Snakes on a Plane

WaffleWarrior Last updated on January 19, 2012
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Team 1


Team 2

LeagueSpy Logo
Middle Lane
Ranked #45 in
Middle Lane
Win 52%
Get More Stats

Ability Sequence

Ability Key Q
Ability Key W
Ability Key E
Ability Key R

Not Updated For Current Season

The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.



Offense: 21

Honor Guard

Defense: 0

Strength of Spirit

Utility: 9

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Hai Guize! Wafflewarrior here to give you a little insight on Cassiopeia. Cassiopeia is a character that i picked up a couple months ago. If i knew how fun she was I would have bought her sooner. However, due to many feeding Cassiopeia's i was a little hesitant on whether she was worth the ip or not. BUT DON'T FRET! She is!

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The many Pros and Few Cons of Cassiopeia


  • Cassiopeia is a very fun champion
  • She is not limited to one specific build
  • She doesn't require a lot of AP to deal a lot of damage
  • She has an AOE stun with a long duration
  • Just broken.


  • Is very difficult to play well
  • Requires smartcast to get the most out of her abilities
  • Difficult Early Game

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Ideal Runes


Greater Mark of Magic Penetration

Greater Quintessence of Ability Power

Greater Quintessence of Magic Penetration

Greater Glyph of Ability Power

Greater Seal of Scaling Mana Regeneration

The runes that i used are pretty straightforward.
  • Magic Penetration Marks and Quints help increase the damage output of your early game by a landslide.
  • The Mana Regen Seals are hopefully self explainable since you are playing Cassiopeia.
  • The extra ability power from Quints and Glpyhs at early game makes it easier for you to farm using your skills and lets you grab an easy first blood.


Alternative Runes


Greater Mark of Magic Penetration-These are pretty much the only marks to use on any Ability Power Champion. I do not suggest you use anything else.


Greater Seal of Armor-These are probably the best runes of its class. It will add some survivability to our build.

greater seal of vitality-The late game HP you will receive will help a lot, so these are also a good choice.

greater seal of replenishment-These are the flat mana regen seals. Overall, Greater Seal of Scaling Mana Regeneration is the best bang for the buck and has better performance.


Greater Glyph of Scaling Ability Power-Excellent runes and can be used. However, i really like the extra early game AP without having to buy a Doran's Ring.

Greater Glyph of Cooldown Reduction- Since we do not buy any CDR items, these runes are very good. So they are a good alternative.


Greater Quintessence of Movement Speed- Movement speed is always a good plus.

Greater Quintessence of Ability Power- Taking all three of these quints is also a very good idea. The downside is its expensiveness.

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So this is the old mastery tree that I have used! With Cassiopeia's passive I don't really worry about mana regen so this offensive mastery tree is perfect. However i have recently changed the mastery tree. You might not have noticed, but compare this one to the one in the cheatsheet.


The reason i do not take spell vamp in the mastery tree is because the spell vamp is pretty unnoticeable.

I made a little tweak to the mastery tree thanks to a suggestion from PsiGuard. Instead of putting 3 into Expanded Mind , I put it into Good Hands . Would you rather have 216 more mana at end game or would you rather have 10% off of your death timer? It might seem like a difficult choice. I assure you, it isn't. Having 216 mana is having an extra 3 noxious blasts. That is nothing compared to going back to lane faster, or respawning quickly to defend after a teamfight goes bad.

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Summoner Spells

I think this list is pretty self explanatory! It's an upside-down pyramid.

You want Flash and Ignite ideally. However, if you are having a hard time landing your skill shots Exhaust might be right for you! Ghost combined with your Noxious Blast gives you super chasing abilities and a getaway.

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Skill Sequence

Ability Sequence
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

Noxious Blast - Cassiopeia blasts an area with a delayed high damage poison, granting her increased Movement Speed if she hits a champion.
Cassiopeia blasts an area with a delayed high damaging poison, dealing 75/115/155/195/235 (+0.9) magic damage over 3 seconds and granting her 15/17.5/20/22.5/25% Movement Speed for 3 seconds if she hits a champion.
35/45/55/65/75 Mana

This skill is what makes Cassiopeia such a good laner. This spell has great range and a very low mana cost. The fact that you are able to spam this skill to harass or farm makes it favorable to max first. The extra speed boost you get when you hit a champion is so potent when chasing or running away from the enemy. Note: Use this skill to check bushes, you will get a speed boost if you hit an enemy in the bush.


Miasma - Cassiopeia releases a cloud of poison, lightly damaging and slowing any enemy that happens to pass through it.
Cassiopeia releases a growing cloud of poison that lasts for 7 seconds. Any enemy that passes through it is poisoned for 2 seconds, dealing 25/35/45/55/65 (+0.15) magic damage each second and slowing them by 15/20/25/30/35%. Continual exposure renews this poison.
70/80/90/100/110 Mana

Miasma is Cassiopeia's least damaging spell. It is more of a utility spell. The slow from Miasma coupled with the speed from Noxious Blast is what makes Cassiopeia so incredibly deadly. There are a variety of ways to use this spell:
  • Your main combo (DUH)
  • To farm (Q+E= entire wave of caster minions dead)
  • To zone (you can push people away from their minions with this spell, so you are able to zone without putting yourself in harm.


Twin Fang - Cassiopeia lets loose a damaging attack at her target. If the target is poisoned the cooldown of this spell is refreshed.
Cassiopeia deals 60/95/130/165/200 (+0.55) magic damage to her target. If the target is poisoned then Twin Fang's cooldown is reduced to 0.5 seconds.
50/60/70/80/90 Mana

Twin Fang is Cassiopeia's constant damage. Make sure you hit Noxious Blast or Miasma before using it. Do not try to spam this skill during your laning phase or you will run out of mana very quickly. Make sure you focus the "Top Priority Enemy" with this spell.

Petrifying Gaze - Cassiopeia releases a swirl of magical energy from her eyes, stunning any enemies in front of her that are facing her and slowing any others with their back turned.
Cassiopeia deals 200/325/450 (+0.6) magic damage to all enemies in front of her. Enemies facing her are stunned for 2 seconds while enemies facing away are slowed by 60%.
120/160/200 Mana

This is one of the best ultimates in the game. Petrifying Gaze scares the **** out of your enemy. You can play some serious mind games with this skill because the enemy team won't know when you are planning to use it. I will go more in-depth on how to use this skill in a later chapter

Deadly Cadence(Passive) - After casting a spell any subsequent spellcasts will cost 10% less for 5 seconds. This ability stacks up to 5 times.

This is one of those passives that you don't really notice and is taken for granted. It helps you a lot during laning phase, allowing you to abuse your Noxious Blast or your Twin Fang.

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As you can see, I have two different Item builds for Cassiopeia. Both builds are extremely potent and both are pretty situational so i advise you to read this section.

Starting Items

  • + 3x (Good against Champs with skill shot harass. ie. Karthus, another Cassiopeia, Morgana, Ezreal)

  • + 2x (Good against champs that YOU can harass.)

  • + (If you got the 9/0/21 mastery (Good if you are confident in your ability to push the other team's mid out of lane.)

Mid-Game Goals

or +

Depending on how your early game goes you want to either have a Rod of Ages or a Rylai's Crystal Scepter. Rod of Ages is unreal in how good it is for your laning phase. It allows you to spam skills without the feeling that mana is a crutch. Rylai's Crystal Scepter is good if you know how to conserve your mana or if you're jungler can constantly give you blue buff. Rabadon's Deathcap requires no explanation.(i hope)

End Game Goals / Finished Build

This build focuses on an easy laning phase which requires you to just farm. You pick up Will of the Ancients pretty late into the game because you have catalyst the protector to keep you sustained early game. This build snowballs into late game very well and requires good positioning.

This build requires you to play smarter. You do not have the mana boost from Rod of Ages so you cannot constantly spam. Early game will be a little more difficult, but you will be able to get to your core items a lot faster. You can buy a Hextech Revolver before you finish your Rylai's Crystal Scepter if you feel that you need more survivability. This build is geared more for organized teams where you know you will be able to get your hand's on blue for a majority of the game. This is also the build you want to take if your team is lacking CC.

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Situational Items

The builds listed above are the ideal builds that you want to have. However, Because this is League of Legends that is impossible. There is no ideal build that you can continually buy every single game. A good player knows that he/she needs to adapt to the situation at hand. These are items that will get you through the game.


Bad Early Game??

Doran Ring A lot of people underestimate the triple Doran's Ring. It gives you health, AP, and the ability to spam.

philosopher's stone Philosopher's stone This gives you some lane stay power and gold per 5.

sight wardWards Buy Wards Noob!


Getting focused?

Quicksilver Sash Highly underrated item that has saved me countless times.


Need End Game Survivability?

Banshee's Veil Similar to Quicksilver Sash but also gives health and mana.

Abyssal Scepter This item works well with Void Staff. It gives you damage and some magic resistance.


Okay Items

Morello's Evil TomeThis item is simply not as good as any of the core items. It gives cooldown reduction which is helpful but it lacks ability power.

Deathfire Grasp A great active but again, it lacks the ability power needed. The active bursts down one person but more ability power will let you shred through all five of the enemies.

Lich Bane Great for pushing towers, especially with Cassiopeia's spammable skills. However, i do not recommend this item since it is very expensive. You won't be able to get an autoattack off in fights if you are busy spamming your Twin Fang and Noxious Blast.


Note: If you are really struggling throughout the game, you can buy Rylai's Crystal Scepter and Rod of Ages in the same build. It is not limited to only one build.

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Archangel's Staff (Yes or No?)



  • Gives you the ability to spam your spells
  • Cheaper than Rod of Ages
  • Gives about 110 ability power at max mana (Not including other mana items)


  • Gives zero survivability
  • Takes a while to build up when compared to Rod of Ages
  • Does not benefit your early game
  • Not needed as much because you should be getting blue buff

In conclusion, Archangel's Staff is a fairly good item just not on Cassiopeia. Cassiopeia is a very squishy mage with only 1730 HP at level 18. Without Rod of Ages she won't be able to stay in a fight dealing constant damage. Catalyst the protector also helps immensely during the laning phase, allowing you to stay in lane all day. Tear of the Goddess just doesn't bring enough to the table. Archangel's Staff is not necessarily situational, but more of preference thing. You can get it if you want, but i am not recommending it.

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How to play Cassiopeia




  • Farming: +
    Throw these two spells onto the caster minions to clear them. You have to last hit the melee minions or Q spam them until they die. This should give you the entire wave, but you should only do this after you get your catalyst so you are able to regain your mana after you level. Use this lazy farming method if you WANT to push the lane.

  • Laning: + + +
    This should be your harass combo. Do not overuse it, because it will drain your mana.

  • Dueling: + + + + +
    If you bush camp until an enemy appears and use this combo, you are almost guaranteed a kill.

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Thank you for reading my guide. I hope this will help you out and/or convince you to buy Cassiopeia. More to come.