Offense

Utility

Akali

Difficulty: 3

A very easy opponent lane with early game as her only harass consists or her Mark of the Assassin with a possible Crescent Slash follow before retreating into a Twilight Shroud. This can all be easily absorbed by your shield and you should harass her when she comes to last hit whenever possible, pushing her out of lane or denying her farm as much as possible. Though when she hits 6 she has a nice gap closer with her Shadow Dance, its damage is still quite weak and can still be effectively absorbed by a good shield on your part. Just don't over-extend too much post-level 6 as her damage can impressive depending how much you've let her farm. if you play your lane well. This laning phase should be a breeze.

TL;DR

Harass her a lot early game.

Deny as much farm as possible

Keep your shield up.

Kassadin

Difficulty: 4(7 Post-level 6)

This isn't really the lane to go for if you're not that familiar with Mordekaiser and his shield. Kassadin is pretty powerful now with his current stats and abilities. His Null Sphere does a great amount of damage all-game round and has a silence that is long and very difficult to deal with, that is if you're not Mordekaiser. That being said. Don't go near Kassadin without your shield up and take care in your lane, especially post-level 6 with his Riftwalk The important thing to do is always place your Siphon of Destruction on him before he hits you with his silence (His is a projectile, and takes time to travel, where as yours does not). Other than that just be very careful with ganks post-level 6 because his combo with his dash on his Riftwalk, the silence on his Null Sphere and the slow on his Force Pulse. Because Whenever he does this, there is a likely chance that there is the enemy jungler on his way to follow up with his abilities, inevitably resulting in your demise.

TL;DR

Hit your spells off first.

Be cautious of his slow and silence.

Be extremely aware of your map and avoid all possible ganking opportunities post-level 6.

If you're new to this match-up, maybe take Cleanse as a summoner spell.

Talon

Difficulty: 6

Talon, like most mid AD-casters, can whittle your shield down by just auto-attacking, which makes AD casters more difficult to lane against, the later the laning phase. His Noxian Diplomacy also deals bleed damage, which can further reduce your shield and health faster if you're not careful. He has a decent slow with Rake a 'blink' and silence with cutthroat and the ability to deal a lot of damage and stealth with Shadow Assault. Like most other ememies, just farm and avoid as many of his abilities and auto-attacks as you can, and be careful of his Rake cutthroat Shadow Assault combo as it deals a ton of damage and can reduce your health to 0 in seconds. His silence and slow also give great opportunity for junglers or enemy laners to gank you.

TL;DR

Dodge his abilities

Avoid his auto attacks

Harass him when possible (He is quite squishy, like most assassins)

Take much care in avoiding ganks

Nidalee

Difficulty: 2

Seriously this is probably one of the easiest champions to lane against as Mordekaiser, just dodge her Javelin Toss, farm, avoid ganks and you're golden. Don't forget to harass!

TL;DR

That was as short as it was going to get anyway.

Lux

Difficulty: 8

This a very pesky champion to deal with, as Mordekaiser, because all of her abilities are really long range, so it's very difficult to harass her, unless she goes in for a last hit, even then it's still difficult. Just play your lane safe and avoid as many of her Light Bindings as possible, because if she's post-level 6, she can hit you with her very dangerous Light Binding, Lucent Singularity, Final Spark combo. The damage is phenomenal, even on an un-fed Lux. Bare in mind than Lucent Singularity is also a slow, and is another possible way that she can help one of her team mates gank you. Not to mention her Final Spark cooldown is very low, especially after she picks up Athene's Unholy Grail, Which most Lux players will have as a first item, because it synergises so well with her.

TL;DR

Dodge ALL of her abilities (Especially her Light Binding).

Never, ever stand still and always be ready for her terrible combo.

Keeping pushing the lane but don't over-extend. Just stay back and wait for the next wave.

If she feeds her combo will do insane damage.

Ryze

Difficulty: 5

Ryze, since the 3.10 patch, has been buffed with his ult but nerfed with his range. This make him a strong follow-up on an initiator and can catch up to you to finish you off. He also relies on farm, so he may not harass you if he feels he should play safe. Take advantages of his item dependency early on and deny as much farm as possible. He can use his abilites a lot, all the time later in the game, and/or he has a blue buff, which makes his harass more powerful than a few other mid laners, constantly throwing his Overload at you every 3 seconds. Bare in mind it also passively decrease his cooldowns by 10% and with full %40 cooldown reduction and his passive Arcane Mastery also helps greatly. He is capable of constantly harassing with his abilities. The only CC he has is his Rune Prison that snares you for 0.75 / 1 / 1.25 / 1.5 / 1.75 seconds. A typical Ryze combo is Overload, Rune Prison, Spell Flux, Overload. Lastly his ultimate Desperate Power gives him a great movement speed and spell vamp buff, also giving his spells AoE damage, this is what you need to be careful for, because with him spamming all of his abilities he can use this frequently and will help him regain his health and deal damage to your and nearby allies and minions.

TL;DR

Try to avoid his snare (and probably his combo).

Denying him all the farm you can.

Deny him blue buff, asking your jungler to counter-jungling or doing it yourself (Though I wouldn't recommend this as you don't even need blue buff and it's risky for Mordekaiser to venture in the jungle alone).

Be cautious of his Desperate Power as he can use it to catch up to you quickly and force a combo onto you.

Take advantage of his item dependency.