For the runes i chose a basic set up, my runes are set up to go top, and mid. I put up x9 seal's of armor which is great for the heavy AD laners like VI, Renekton, Zed, etc... This is also good so that if you are playing against a ranged AD then they wont do as much damage to you. For the marks i put x9 Mark of attack damage which is good so that in the beginning of the game you wont have to buy any attack items. you can if you want but when i play kha'zix from the beginning i get to at least 77 attack without an ion sword or doran sword. The next thing i put are x9 glyph's of magic resist which is vry good if you are going up against a vlad or a morde. The last runes i put are the x3 quints of attack damage which is good also. But if you want you can put quints of armor penetration. It helps with his Q skill.