Runes

• Greater Mark of Magic Penetration:
  With these runes you got some nice magic penetration which helps a lot throughout the whole game. In my opinion, these are the only viable Marks for mages.
• Greater Glyph of Scaling Ability Power:
  Since Karma isn't a AD champion (obviously). We can use these to build up her magic damage. With these, you will have a nice amount of AP at the start of the match.
• Greater Seal of Mana Regeneration:
  I take 9x Greater Seal of Mana Regeneration because Karma can be very mana hungry. I do not recommend taking Greater Seal of Scaling Mana Regeneration, because from the moment you have your Athene's Unholy Grail, mana won't be such a problem anymore. I really recommend taking flat instead of scaling.
• Greater Quintessence of Ability Power:
  You may wonder why I go for flat AP and not for AP/lvl well that's because AP/lvl Quintessences are pretty bad they won't be better than the flat ones until lvl 12.
  Greater Quintessence of Ability Power great for some more early damage.

Other Marks

Other Seals

Other Glyphs

Other Quints

Items

Start with:

We take a Faerie Charm 5 Health Potions and 2 Mana Potions because we want to stay in lane as long as possible and farm. If you want, you can buy 2 Faerie Charms, a sight ward and a potion of your choice if you feel you have already won your lane. We don't need to start with boots because your Inner Flame has enough range for you to poke and farm safely.

Next:

and

We need Chalice of Harmony for those iffy mana problems after spamming too many Inner Flames or using Inspire too much. The boots are so you can run away quicker because once you get caught by someone like Master Yi, you will hurt.

Get a staple item:

or Catalyst the Protector or

This is the item you will have with you for a while that will help you until you get one of your more powerful items. Doran's Ring is if you're behind or above in creep score. Catalyst the protector is if you would like Karma to have a bigger mana and health pool. Seems logical since it builds into Rod of Ages. Frostfang is veryyy useful. It builds into a variety of useful items and it can help you get to your Rabadon's Deathcap. Also, if you have been pushed to your tower, you can autoattack for gold. Although if you choose Catalyst the Protector, you'll lose your extra gold from not buying Frostfang. But its okay if you choose Catalyst if you're a new player. The Frostfang route is usually for advanced players who can manage their mana better and play safer.

Must Buy Items:

and

These are one of the best two items on Karma. Why? Because Karma is a AP carry of course! Athene's Unholy Grail supplies everything you need while mid. Mana, Magic Resist, AP, and a sweet passive that gives you more mana. Rabadon's Deathcap is a must for all AP carries. It just is. It gives you a TON of AP.

One Utility & Damage Item:

or or

Choose one of these. Liandry's Anguish gives you that extra magic penetration. Deathfire Grasp is if you want another item that gives you 100 more AP. The passive can be put to use if the enemy team has someone like Jax. Since they're in your range, that active can be put to use. The cooldown reduction is also nice. I chose Morellonomicon to be here because it grants something Karma needs. Cooldown reduction. Also, since you are the one to be helping out in teamfights, its passive can help reduce the effect of their heals.

One Defensive Damage Item:

or

These two are really good as far as I'm concerned. Rod of Ages builds straight from one of your staple items. It gives you some health, mana, and AP. Most who aren't a fan of Rylai's Crystal Scepter go for this. As for me, I choose Rylai's Crystal Scepter. It's passive ability goes well with your Focused Resolve. But it doesn't just proc with that, of course it procs with all your other abilities. Another reason why I choose Rylai's is because Defiance damages all enemies in the range. In teamfights, its mostly just a sh*tsstorm of fighting where one last living teammate ends up running away to prevent their death. Well, a Mantra'd Inspire hinders that opportunity.

One Final Item:

or or

I chose these three because they can apply to the situation of the game. Void Staff is pushing the amount of Magic Penetration you already have to a great amount -also granting AP. Zhonya's Hourglass gives you a nice amount of armor plus a passive that protects you for a few seconds. Get this if the other team has more AD champions. Finally, Abyssal Mask is if the other team has alot of AP champions. Its passive also works well because she can have a bigger effect on teamfights.

How to avoid the enemy jungler while mid laning.

• Map Awareness! <--- If you're paranoid like me when you see a enemy not in their lane via the map. Run back to green zone of your lane if you think you cant handle a potential ganker.
• Use wards! <--- Basically, if the mid bushes are warded. Screw the safety zone chart and just look at the map. If a enemy is heading toward mid you can easily run back to the green zone on your own.
• Have members call mias! <--Get the heads up and be aware.
• Use tab! <--Pressing the tab key shows the scores of ALL players. It even shows how long a enemy is dead! You can manipulate this to be in the red zone without worry. So as long as your aware of whos in their lane, you can destroy that turret!
• Use Smart Ping <-- Thank god they added this in. Your allies can alert you more specifically.

Changelog

• March 28, 2013 - Guide Launched!
• March 30, 2013 - Removed Support Section due to popular demand.
• March 31, 2013 - Added beautiful headers thanks to Xiaowiriamu!
• March 31, 2013 - Added in the "Items" & "Situational Items" section.
• March 31, 2013 - Made it as the #1 Karma guide on Mobafire!
• April 10, 2013 - Support Build is in!
• January 27, 2014 - Matchups Section is in progress