Now, before getting into all that I figured it would be a good idea to tell something about myself. I am Katasandra, a Lissandra onetrick playing on the EUW server. I am mostly to be found chilling in normal and ARAM games as I do not have the time and drive to grind ranked. I started playing Lissandra slightly after the runes rework (2017) and have accumulated over a thousand games & a million mastery points by now.

Lissandra doesn't have a high complexity like Akali or Yasuo, she's also not really like traditional mages that deal heavy damage while staying at a distance. So why would you want to play this chilly ice witch?

In a nutshell, Lissandra is a weak laner. However, if the enemy gives you freedom or you manage to create some yourself, you can get some pretty good roams. Past the laning phase she starts to show her true self, where she excels in skirmishes and making picks. Once she gets a few items she transforms in a teamfight menace due to her AoE damage and CC.

One thing that stands out to me is her agency. Where other champions, mage or assassin, have to pick their moment very carefully, you can decide it will happen now. Her CC and AoE in combination with Glacial Path can easily lead to victory by your hand or demise...

Despite this, Lissandra is definitely not a flashy champ. Although she is very capable of pulling off highlight plays (most notable massive AoE combo's in teamfights), they are not what defines her. You'll find people accusing you of being a "press R champ" or "your jungler ganks so you win champ". This game isn't some honorable duel, it's dirty and unfair. It is often not possible to out-mechanic other champions as Lissandra and therefore she finds other ways...

Finally, be aware of her conflicting identities. She likes to fight up close, like Vladimir and Swain, but she doesn't have the survivability they do. She has glimpses of zone control, but doesn't have quite the damage or range as traditional control mages. And last but not least, she is very skewed towards burst damage, but fails to reach the same heights as champions like Syndra and Annie. Lissandra has a bit of everything, but excels at none.

Interested? The cold, bitter touch of true ice beckons you to continue reading...

In a way, the section above already (implicitly) lists a lot of Lissandra's pros. However I didn't list the cons yet and as I am a fan of lists, here is an overview:
Due to Lissandra's versatility, she works in/against a lot of teamcomps. Nonetheless there are teamcomps that feel better to play against, and there are also things that make you go "ughhh" in champ select.

So what does this popsicle woman do exactly? Here's a basic breakdown of each ability.
If you're looking for more in-depth tips & tricks >>go here<<!Whenever you kill someone or an emey dies near you, they'll spawn an ice zombie. This zombie slows enemies, chases them and explodes after a few seconds.
This passive literally plays the game by itself. All you have to do is not die. Occasionally it pays off to walk around your thralls/force enemies to walk through your thralls. Be aware that these can add some extra damage, which can let you snowball fights after the initial burst.
Linear skillshot that deals (the same) damage to everything in its path. It only slows the first enemy hit and its range extends if it hits something.
This is Lissandra's bread-and-butter ability. It is her main damage tool throughout the game and her only damage source that doesn't require her to be very close to enemies. Try to hit as many enemies as possible whenever you fight!
AoE instant root that deals magic damage.
An extremely straightforward ability. It is mostly used in conjunction with other abilities (+ Ice Shard for burst; after Glacial Path for CC; before self- Frozen Tomb to guarantee damage; to CC chain/kite together with Ice Shard/ Frozen Tomb). The damage can sometimes be as impactful as the root. Unfortunately, the range can be a bit tricky sometimes.

Remember this: better get a lil too close to the enemy than not hitting the enemy at all.
Cast a claw of ice that moves forward and deals damage. Reactivating teleports you to the location of the claw.
This ability is what makes Lissandra fun compared to a lot of other champions. It let's you dive on top of enemy champions, or escape from nasty situations. Avoid wasting it as it will cost you dearly because of its cooldown. Also bear in mind that the enemies can see where the claw will end up, the only thing they do not know is when you will reactivate it (if at all!).
Stuns an enemy, or puts you in stasis and heals you. It also creates a damaging field around the target that slowly spreads out and slows enemies as well.
This is Lissandra's fantastic ultimate. It allows you to catch enemies' by CC-locking them for days. Or you can hop in the middle of the enemy team, go into stasis and deal a ton of damage. And last but not least, you can use it to protect your allies and shut down mobile enemies.

Disguised as 'press R to win', but it is actually much more than that!

Use Hotkeys to Selfult!

If you still don't feel sure about whether to take Teleport or Ignite, just try both of them for a few games and see how they feel and what you can do with them. You'll notice that they give you different options in terms of playstyle and neither of them is 'right' or 'wrong'. Don't overthink it and just go with the flow :)

Keystone & minor runes

Alternatives

One comment that frequently pops up in the Lissmains Discord/Reddit is the fact that Electrocute is hard to proc in lane. This is true, it's harder to proc it compared to a lot of other champions (more in-depth talk about this in the gameplay section). So for those of you that find it hard to get used to Electrocute or just want a keystone that's more useful in lane:

The minor runes to go along with it are Manaflow Band, Transcendence and Gathering Storm. For the secondary tree there are three things you can pick: Resolve for extra defenses which can help a great deal when jumping into things (you can also run Resolve with Electrocute). This is by far the most 'beginner friendly' page as the extra defenses help with not dying while you get used to Lissandra's close-ranged nature. Inspiration or Domination, both of which give lane sustain ( Biscuit Delivery, Taste of Blood), but give different additional benefits (e.g. Hunter runes vs Cosmic Insight).

Lastly, here's a general overview of all the minor runes I consider to (not) be viable on Lissandra:
In the spoiler below there is an explanation on some of the runes. I won't repeat things I said above and if I don't mention a rune at all, it means that it doesn't synergize with Lissandra at all. I do not give a concise summary of take X or take Y. The choice depends on your playstyle, just as Riot intended it to be...

Rune shards

Starting items

The premier starting item is Doran's Ring (+2x Health Potion). It synergizes well with what you want to do as Lissandra early: farm and chill.

Then there's also Corrupting Potion. The major advantage of Corrupting over Doran's is that it gives more mana sustain + burn on abilities/autoattacks. This makes it ideal if you were to lane aggressively and burn through your mana rather quickly. This is pretty much only possible in melee (assassin) matchups. Think of things like Yone, Fizz, Katarina and Akali. To increase combat power you can combine it with Biscuit Delivery and Time Warp Tonic. The 'burst' healing can save your life in close fights.

All that being said, playing this aggressive is a personal choice. It could help create a lead, but at the same time, playing even against these assassins means that you're winning. That's why I myself prefer to stick with Doran's Ring and play the game a bit slower.

First base

Mythics

Legendaries

Builds and allies

When choosing your items, it is important to take your allies' items into account. For example, if you have an AP jungler that decided to build Liandry's Anguish, you should avoid building that item because the burn doesn't stack.

If you have a lot of allies that are building tank/defensive items, try going into pure damage yourself. Unless your team is significantly ahead, everyone building defenses might lead to a lack of damage. This also applies to grievous wounds: if your team already has 3-4 people building it, it makes no sense to also get it yourself.

Last but not least, if you aren't doing too hot (you're feeding), but your team is doing well. Focus on 'utility' options, like Morellonomicon, Zhonya's Hourglass or even a Abyssal Mask. It is not really your job to do damage, but to stick with your teammates so that they can.

Laning phase

Laning phase can roughly be divided into two parts: the early laning phase and the late laning phase. The former is the window between levels 1-6 and the latter is from level 6 till midgame.

Early laning phase

In this phase of the game, your main objective is farming. Sometimes you'll end up killing your opponent, but getting ahead (or putting them behind) is not your main objective. You also won't have to worry about roaming yet, but perhaps your jungler (or the enemy's) will grace your lane.
At this point in the game, you essentially have three important 'abilities': your autoattacks, Ice Shard and your minions. Ring of Frost and Glacial Path are only used situationally. Ring of Frost is used in all-ins or when setting up a gank for your jungler, or when a melee champion starts trading with you. Glacial Path is only used in all-ins or to escape ganks.

Especially in the early laning phase, you cannot spam Ice Shard. You'll run out of mana in no time. Use autoattacks to pick up CS, most of the trading will be done with autoattacks as well.
In melee matchups you should look to damage the minions such that your minions have slightly more health than the enemies. This will make the wave slowly push towards the enemy side. Keep lasthitting/maintaining a minion health lead till the wave crashes. While doing this you should look to harass the enemy with autoattacks and/or Ice Shard when they go for CS. Make sure to hit not too many minions with Ice Shard as that may make the wave push too fast.
Note that I use Ring of Frost here. Since Yone is only lvl 1 he cannot jump on me and I can use it for harass. Otherwise I'd save it for his Soul Unbound. Also notice that I retreat immediately after proccing Electrocute. If I stay the ranged minions will do massive amounts of damage.
After hitting the tower the minion wave starts slowpushing back to you. Make sure it does so (do not push it back). Now you have to be a bit careful about harassing because you got less minions around you. You can choose to either thin the wave and setup a freeze, or you can let the wave crash into your tower and start another slowpush. In case you need to base you can spam Ice Shard on the wave.

Versus ranged matchups the gameplan isn't so straightforward. A lot of mages struggle with farming under their tower ( Vladimir, Lux, Veigar, etc) so trying to push them in can be a good idea. Also, pushing an enemy to their tower forces them to use spells to farm, so they can't use them to poke you. On the other hand, pushing does make you vulnerable to ganks. Although Glacial Path exists, you can still take a sizeable amount of damage if a jungler decides to gank.

The main objective is to farm, you can try to push the wave before scuttle spawns so you can accompany/help your jungler. When you are level 5 you can push the wave into the enemy, base and get fresh items so you can look for a kill/roam once you hit 6.
As Lissandra your trades are either quick pokes (autoattacks, Ice Shard) or small rotations where you proc Electrocute. (AA - Ice Shard - AA; AA - auto - Ice Shard). If melees jump into you ( Ring of Frost - AA - Ice Shard - AA) is common as well.

Either trade when the enemy goes for CS or when one/multiple of their abilities are down. Also be careful around minions, avoid autoattacking the enemy when you're close to the ranged creeps/the enemy minion wave is very big.
Especially in melee matchups, autoattacking is extremely important. Not only weaving them between abilities, but also when the enemy starts retreating. A lot of people scuttle away in fear, but since the enemy just burned all of their abilities you should chase them a bit with autoattacks. This can really make the difference between you trading even/winning the trade and losing it really hard!

In the example above, as soon as the Sylas tries to go onto me all my minions start hitting him. This can also do loads of damage and help you win trades (or lose them, if the enemy cannon/ranged creeps start hitting you). Be aware of this, stay near your minions or be careful when you do not have a lot of them around you.

Late laning phase

In this phase of poking with Ice Shard and shoving the wave & roaming becomes more important. Especially in ranged matchups you should rarely look to proc Electrocute utilizing autoattacks. Most of the time you chip them down from a distance with Ice Shard (or just don't interact at all). You can Glacial Path forward when the enemy wastes an important ability ( Scatter the Weak, Sleepy Trouble Bubble, Pick A Card), but be careful of the enemy jungler!

If your own jungler ganks your lane, Glacial Path forward and either use Ring of Frost or Frozen Tomb. Then use the other CC ability right before the CC effect of the former expires. The enemy laner either dies or has to burn all their summoners. If your jungler has any kind of CC you can also try to play around that.

In some matchups you'll find that you get completely outmatched or fall behind. In that case, just try to farm and avoid fighting with your opponent. If you can walk up to the wave & hit it, do so. But if that isn't possible, wait for the wave to come to you.

You can also look to push the wave and roam. If there isn't anywhere to roam to, just sit out of vision or place a ward. If your opponent roams, only follow if you have vision and you're very close behind them. If you are very far behind them you won't be able to help much, just stay mid, push the wave & try to get a plate.

Midgame

At some point in the late laning phase skirmishing starts to become important (drake fights, botlane parties). Your main goal is picking off targets and bursting them. Your damage won't be that flattering yet and your CC will be much more valuable.

Whether you want to fight or not depends on your ultimate and objectives: you do not want to fight when Frozen Tomb is on cooldown and you do not want to use it right before objectives spawn (because then fighting over that objective becomes pretty hard).

You should always be on the lookout for picks: enemies that run around alone and end up within your range. If you can oneshot the enemy, you can look to do this on your own. But if you cannot you should look to stay near some of your allies so they can follow up.

Once the botlane tower falls the game moves into the phase called the midgame. Your ADC might move to midlane and farm over there. You should vacate the empty lane to avoid sharing farm. If there is a lot of fighting happening for no reason, it is often better to stick with your team. Although having less farm sucks, if you aren't present the game can easily swing out of control if your team loses these fights.

In skirmishes you should look to pick off important targets/burst enemies. For example if there is a fight over the drake I will be trying to single out the enemy jungler. Of course if the enemy ADC or midlane are out of position I can turn onto them as well.

Teamfighting

Teamfighting defines whether a Lissandra player is good or not. There is a thin line between life and death and you have to walk that. In some games it is very easy, as the enemy team decided to clump up and you just hop in there for a 4-5 man combo. In other games the enemies stay away from each other, they got heavy peel or maybe you are behind and then life ain't as easy.

I play a fair bit of ARAM and also run into a fair amount of Lissandra's there. The main issues I see is that they either going in too eagerly (like a tank/engage) or being too slow when jumping in (enemies can run away/get CCed and die). It is extremely easy for you to jump into the enemy team, but a lot of the time this will lead to your doom. Although Lissandra is not a mechanical champion, you need to execute combo's at high speed. If you are too slow either the enemies get away or you get CCed and die.
Lissandra has a signature combo: E - E - (F) - W - Q - self R - (Q - Zhonya - Q - E - W - E).

This combo is the 'standard' whenever you dive in the middle of the enemy team. And it is very important to execute it quickly. You need to limit the time window where you are vulnerable. It is necessary to understand where the damage of this combo comes from: about 1/3th is from Ice Shard, 1/3th is from Frozen Tomb and the last 1/3th is from Ring of Frost + Electrocute. In some fights throwing Ice Shard can be dangerous due to CC (as it's cast time increases the window of vulnerability), however not using it means you'll miss out on a lot of damage. I personally always throw Ice Shard as not throwing it means that there is no point in diving in the first place.

Always use hotkeys to selfult. It's faster and it's more consistent. You can either use ALT + R or set another keybind in the settings.
In some games diving will not be an option. Then you should look to play front-to-back. CC their divers and/or CC their frontline. This will happen mostly where the enemy team has a lot of tanks/bruisers or enchanters. It is hard to do threatening damage to both of these due to their HP or shielding. Therefore you should focus less on diving and more on keeping your own team safe. In these kinds of fights you'll rely a lot on spamming Ice Shard and continuously using Glacial Path to reposition. Therefore having high amounts of haste ( Cosmic Drive, wink wink) is favored over stacking flat damage.

There is not really a set way of using your abilities in these types of fights. Most of the time you spam Ice Shard, use Ring of Frost to CC divers/frontline. Hold Frozen Tomb for defining moments, to either make sure an enemy dies, to prevent the enemy team from running into your team or to protect yourself.

❄ Has a high base damage so is effective even when behind.❄ Multiple thralls exploding at the same time will deal massive damage❄ Walk into/around thralls so that enemies have to follow you through them.❄ If you have Zhonya's Hourglass you can activate it to buy time for the passive explosion.Thralls can really contribute to your damage. It turns out that it outdamages all other abilities (except Frozen Tomb at high AP numbers). This is true for one thrall already, so spawning multiple can do a lot of damage:
You can incorporate the thrall explosion in your combo to kill an enemy. The best way to do is to chain CC them just so that they'll be unable to move right when the passive explodes.

Last but not least, if you're certain that a passive explosion will kill an enemy you can walk away (+ mastery emote) to flex on your enemies (if you're into that sort of thing). Warning: this can backfire Of course, before the thrall goes boom it needs to hug an enemy. If your enemies are running away from you, getting them to stay next to one is quite difficult (or even impossible). On the other hand, if they're trying to kill you can attempt to walk them into your passive. Sometimes this means walking away from the enemy in a straight line, sometimes this means wandering in all kinds of directions (the Thrall will help with this since it applies a slow).

Of course, only run into directions that won't get you killed. If you're really close to dying and you're being chased by a full HP enemy it might be a better idea to choose the shortest path to safety.

You can also use Frozen Tomb and Zhonya's Hourglass to buy time for the passive to explode. Often when you enter stasis, people will sit around and wait for you to come out (despite your passive sitting right there). This can swing fights in your favor! ❄ Only slows the first target hit❄ Has a small cast time❄ Do not spam this ability early on, you'll run out of mana!❄ Use it to check bushes: it'll shatter if someone is in it The max range of this ability increases once you hit something, but unfortunately there isn't any kind of indicator that shows this range. Finding it requires fiddling some time in practice tool, a lot of games and the knowledge that the range goes a little bit beyond the particle effect (Bazinga!). Fortunately, I made a vid that shows this range:
Unlike a lot of other abilities, it is not possible to Flash buffer Ice Shard. (E.g. when you cast an ability and Flash during the windup time it will be fired from your new position). So if you want to Flash + Ice Shard to kill an enemy, you should make sure you don't cast them in the wrong order or you look like an idiot.

This mechanic can also be used to your advantage. Ice Shard - Flash can be used to create more distance when kiting away. However it can also be used for some really fast all-in combo's.
This ability is your main waveclear tool and you got to use it correctly. If you want to shove/clear the wave you should hit the entire wave with a single Ice Shard. This often requires you to stand in specific spots as you'll only hit 5/6 minions otherwise.
You shouldn't look to hit as many minions as possible with Ice Shard. You should also look to hit as many champions with a single Ice Shard in fights. Taking half a second to reposition so you can hit two people instead of one can be worth it!
Regardless of whether you are fighting minions or champions, try to hit as many targets as possible. If you need half a second to reposition to hit two people instead of one it is worth it.❄ Has no cast time: can be used while moving❄ Does not interrupt dashes❄ One of, if not the only ability in the game with hard CC without a cast time.❄ Is not a projectile, goes through abilities such as Yasuo's Wind Wall and Braum's Unbreakable❄ The range is center to center, it might be a bit lower than it seems The main trick of this ability lies in knowing it's max range.The most important detail of Ring of Frost is that it has no cast time. This means that it can be used while moving and it can be used for instantaneous lockdown after using Flash or Glacial Path, leaving enemies with no time to react.

This can be used at all points in the game, whether roaming to botlane or in teamfights, as the main teamfight combo makes use of this.
It's AoE radius also makes it an excellent ability for catching invisible targets. If it hits one, a outline will show. Your team and you can throw abilities at the enemies' location, which will kill them more often than not.
❄ Cannot be recasted when you're disabled (stunned, grounded, silenced, etc)❄ Don't panic if you get stunned; the claw needs ~1.5s to travel to the end location and can be reactivated ~0.2s after it vanishes. You might still be able to teleport after the CC ends (Just keep mashing that button!).❄ Reactivate Glacial Path after it has traveled a short distance or after it has vanished to surprise your enemies❄ The enemy can see the indicator as long as they are within range (600 units) of it❄ The speed of the claw is not constant, it goes faster at the start and slows down at the end
The travel speed of the claw almost halves over the duration. Unless you want to surprise enemies it is rarely useful to wait for it to get to it's maximum range (especially since enemies will run away from it).You can do really dope things with this ability. I don't know where to start! So let's start with the coolest thing: you can dodge skillshots with it.
This is almost always done preemptively: you see an enemy walk at you (for example: Gragas is ganking you). You know he's going to use a skillshot and therefore cast Glacial Path. Then as soon as you see them throw the skillshot, reactivate Glacial Path.
An extremely common use is to use Glacial Path over the nexus to get to lane faster. This saves a few seconds which can result in you not missing xp/gold to the tower. It is also a way to extend the homeguard buff as you can cast Glacial Path, run back into the fountain and reactivate.
If Glacial Path is on cooldown at the time, you can also use it a little later to save time anyway. The travel speed of the claw (1200-640) is almost always greater than your own movement speed.
You can recast Glacial Path for about 1.8s. If you end up getting CCed after casting it, keep trying to recast it (once the CC times out) in some cases you can still get out.
In general, whenever enemies have CC available, make sure to stay out of their range after you cast Glacial Path or recast it to dodge whatever skillshot they throw at you.
When all-inning/soloing opponents you can time Glacial Path such that it can be recasted slightly after the CC on my target ends. In case you do not have enough damage to immediately oneshot them, you can follow enemies once they try to flee from me. This greatly limits their escape routes and most of the time will result in their death since you can throw another Ice Shard.
Glacial Path can also be used like this when diving turrets. You essentially use it on the enemy and reactivate to get out. But again, this combo can be very dangerous if there are other enemies nearby.

Last but not least, wall jumping. With Glacial Path you can cross about any wall in Summoners Rift (as long as the claw is halfway through). But there are some places where you can cross two walls at once, shown on the map below. This can come in really handy for escape maneuvers. I recommend trying them a few times in practice tool, if you randomly try them ingame you might end up smacking your face into a wall.

The jumps I end up using most of the time are the ones around the tribush areas and the ones to/from the drake/baron pits (but not the ones to the red buff). The jumps to the T1 turret are also handy sometimes.
❄ Use hotkeys to self ult! You can assign these in Options > Hotkeys > Abilities and Summoner Spells > Self cast (spell 4) (Or use ALT + R). This is vital for speed and preventing accidents! ❄ Frozen Tomb will damage (and slow) anything on top of the target instantly. At rank 3 the slow is almost as powerful as the stun. ❄ If you cast Frozen Tomb from max range, make sure to walk a little towards the enemy before using Ring of Frost.
❄ Space out the timings of Frozen Tomb and Ring of Frost to CC enemies as long as possible.
❄ You cast Frozen Tomb on a target that is not in range and then use Flash and it will cast instantaneously. This makes it almost impossible for your target to react.
❄ Not only who you ult is important, the place where you ult is important too.
One (uncommon) use of Frozen Tomb is to avoid lethal damage. Whether it be Ignite, Death Mark or Requiem. It won't do damage as long as you're in stasis.
Frozen Tomb also has a knockdown effect: it interrupts dashes. Unfortunately, it is hard to interrupt dashes consistently due to it's cast time. Most of the time you'll only interrupt 'slow' dashes (such as Rocket Jump). For the rest you'll have to use it preemtively (e.g. Lee Sin stuck in the drake pit walking towards the wall, enemies attacking blast cones, interrupting Dark Passage).
If you Frozen Tomb too late, the dash can complete but the ultimate will follow enemies. This often leads to wonky situations where you (seemingly) ult enemies that are out of range. It can then be hard to chain CC them with Ring of Frost due to the increased distance (although having a Luden's Tempest makes this significantly easier due to the MS).
As Lissandra you can easily towerdive enemies with Frozen Tomb. There is the way all other champions do it: they walk in and out of range to juggle aggro while dumping abilities on whoever is under the tower. Or you grab turret aggro, you get on top of the enemies and then you Frozen Tomb yourself to reset the turret aggro.
This can be done when diving midlane, toplane, botlane, whatnot. Just make sure you can actually leave the tower range after you've ulted yourself. Since Lissandra has multiple sources of CC at her disposal, you should spread them out such that enemies get CCed for the maximum amount of time. The key thing to keep an eye on is the CC bar that's just above the enemies' health bar:

Once you use your first CC ability, you should time your next on such that it applies the CC just before the bar vanishes (let the CC overlap a little bit, otherwise there might be a small gap where the enemy can use Flash). This is very easy to do with Ring of Frost since it has an instant cast time, but requires some practice with Frozen Tomb and Everfrost due to their cast/travel times.
The order of the abilities depends on the situation, but every ability/item has a certain advantage over the others:

• Frozen Tomb: Guaranteed mid-range lockdown, stuns
• Everfrost: Long range, no commitment
• Ring of Frost: Instantaneous lockdown

Because Ring of Frost is instantaneous you should always use it right before self- Frozen Tomb. The root guarantees the spread damage. If you hit people at the edge of Ring of Frost, the slow zone of Frozen Tomb will slowly crawl out before eventually hitting the enemy and possibly killing them.

Together with an Ice Shard this can do up to 2.6k(!) damage (Maximum at full build, lvl 18, vs a target with 70MR). This is often enough to delete any ADC/mid laner as long as they do not have extra health/shielding.
It is possible to cancel Frozen Tomb and Ice Shard animations by using them right before reactivating Glacial Path.
Canceling Frozen Tomb' is extremely rare. However, animation canceling Ice Shard is quite common. Whenever you use Glacial Path as an escape, you can throw Ice Shard at the enemy without repercussions. Especially if they are chasing you this can be a good idea as the slow will make it harder for them to catch up.

Instead of Ice Shard you can also use Ring of Frost (but since that ability is instant, it's not an animation cancel). You can also combine those two abilities:
The main trading combo is AA - Q - AA. It is the most 'fluid' way of proccing Electrocute in the laning phase. Having an attack speed shard makes this combo quite fluid, which is why I recommend to take that shard at all times.
There are also other ways to proc Electrocute. These are used less, or in other scenario's. Used to all-in your opponent before level 6, or if your ult is on cooldown. The damage varies depending on level. Having Ignite can make a big difference, especially at lower levels. Most enemies will Flash away from you as soon as Ring of Frost root ends, but you can reactivate Glacial Path to follow them. Be careful of the enemy jungler since you're using both your escapes offensively (or alternatively, do not use Glacial Path).
A common combo to all-in your opponent after level 6. You can switch Frozen Tomb and Ring of Frost (if the enemy is range of the latter). Using Ring of Frost first is slightly more reliable as it does not have a cast time. This combo is also often used when setting up a gank for your jungler. Weaving autoattacks is very important, they can make the difference between killing an enemy and them surviving.
This combo also continues to be used throughout the game (without weaving autoattacks) to pick off targets. The trick is to use Glacial Path to reposition such that you can hit your intended target, but other enemies cannot collapse onto you (In other words, don't yeet yourself in the middle of the enemy team). It (again) is more reliable to lead with Ring of Frost. This will also lead to Electrocute proccing on Frozen Tomb cast, which results in a decent amount of damage.

As seen in the clip, it is custom to retreat a bit after casting Ring of Frost. The main reason for this is to reduce the chances of retaliation of the enemy team. This is possible since Frozen Tomb's range is slightly larger. The combo is extremely effective in chokepoints as the enemy team has to run over Frozen Tomb to get to you. Lissandra's staple combo. If you have 60 haste or higher, you can use Ice Shard right after Frozen Tomb stasis ends. This combo can make or break teamfights, by either removing key carries from the fight in an instant or dealing massive AoE damage overall.

The engage range of this combo is quite high, so should you use it you have to make sure your team is able to follow up. Even if you land a very good combo, if your team is not nearby it might be wasted anyway.
Note that Everfrost can be used in these combo's as well. ( Everfrost - Ice Shard is slightly smoother than vice versa). However, I do not recommend using it like that. Try to utilize the root, rather then treating it like a budget Luden's Tempest.